4-Chlorobenzhydrylchloride Chemical Properties

Boiling point:

159-160 °C2 mm Hg(lit.)

Density 

1.239 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.603(lit.)

Flash point:

>230 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly)

form 

clear liquid

color 

Colorless to Light yellow to Light orange

Water Solubility 

IMMISCIBLE

Sensitive 

Moisture Sensitive

BRN 

2050236

CAS DataBase Reference

134-83-8(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1-chloro-4-(chlorophenylmethyl)-(134-83-8)

EPA Substance Registry System

Benzene, 1-chloro-4-(chlorophenylmethyl)- (134-83-8)

Safety Information

Hazard Codes 

C

Risk Statements 

34-36/37-36

Safety Statements 

26-27-36/37/39-45

RIDADR 

UN 3265 8/PG 2

WGK Germany 

3

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

HS Code 

29036990

MSDS

• Language:English Provider:Chloro(4-chlorophenyl)phenylmethane
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Chlorobenzhydrylchloride Usage And Synthesis

Chemical Properties

clear light yellow liquid

Uses

1-Chloro-4-(chlorophenylmethyl)benzene is used in the synthesis of novel benzhydrylpiperazine derivatives as cytotoxic compounds in the treatment of various cancers.

Preparation

Preparation of 4-Chlorobenzhydryl Chloride (4-CBC): The 4-chlorobenzhydrol (4-CB) in 15 mL of toluene, obtained from the previous step, was mixed with 10 mL of conc. HCl at 60oC maintained at the same temperature for 2.5 h. The reaction mixture was cooled to 20oC to separate into organic and aqueous layers. The toluene layer was washed with 10 % aq. sodium carbonate to pH 7, dried over anhydrous sodium sulphate and taken to next step without isolation.

4-Chlorobenzhydrylchloride(134-83-8)Related Product Information

• 4,4'-Methylenedianiline
• Triphenylmethyl Chloride
• Chloromethane
• Chlorodiphenylmethane
• Benzene
• Diphenylmethane
• 3,4'-DIAMINODIPHENYLMETHANE
• Diphenyldichloromethane
• Chlorofluoromethane
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• Difluorochloromethane
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• 4,4'-(ALPHA,4-DICHLOROBENZYLIDENE)BIS[2,2'-(PHENYLIMINO)DIETHANOL]
• 1,1'-(chloromethylene)bis[4-chlorobenzene]
• 4-Chlorobenzhydrylchloride
• dichloro[(dichlorophenyl)methyl]methylbenzene
• AKOS 94028