4-Chlorobenzhydrol Chemical Properties

Melting point:

58-60 °C (lit.)

Boiling point:

150-151°C 2,6mm

Density 

1.1178 (rough estimate)

refractive index 

1.5260 (estimate)

Flash point:

150-151°C/2.6mm

storage temp. 

2-8°C

solubility 

insoluble

pka

13.34±0.20(Predicted)

color 

White to Off-White

Water Solubility 

insoluble

BRN 

2050235

CAS DataBase Reference

119-56-2(CAS DataBase Reference)

NIST Chemistry Reference

Benzenemethanol, 4-chloro-«alpha»-phenyl-(119-56-2)

EPA Substance Registry System

Benzenemethanol, 4-chloro-.alpha.-phenyl- (119-56-2)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

24/25-36-26

WGK Germany 

3

TSCA 

Yes

HS Code 

29062990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-Chlorobenzhydrol Usage And Synthesis

Chemical Properties

white crystalline powder

Uses

4-Chlorobenzhydrol was used as internal standard to measure the N-demethyl antipyrine metabolite in urine by gas chromatography-mass spectrometry. It was also used in the identification of the antihistamine cetirizine as a relevant cross-reactant for the carbamazepine-specific enzyme-linked immunosorbent assay .

Preparation

Preparation of 4-Chlorobenzhydrol(4-CB):
about 5.0g(0.023 mol) of 4-chloro benzophenone was dissolved in 15 mL of isopropyl alcohol (IPA) and heated to 50°C followed by the addition of 0.265g(0.007 mol) of sodium borohydride as a lot with the temperature maintained at 65°C for 2 h. The reaction mixture was distilled to expel isopropyl alcohol up to 90 %. The resulting solution was cooled and treated with dil HCl (5 mL of conc. HCl in 20 mL of water). Finally the reaction mass was extracted with 15 mL of toluene. The toluene extract was washed withwater to pH-7. The compound obtained in this step was taken to next step without isolation but aliquot sample was concentrated, isolated and checked for melting point (m.p. = 58-60°C).

Definition

ChEBI: P-Chlorobenzhydrol is a diarylmethane.

4-Chlorobenzhydrol(119-56-2)Related Product Information

• Ethyl acetate
• Benzyl alcohol
• Benzhydrol
• 2-(2-Hydroxyethyl)pyridine
• 2-Vinylpyridine
• (RS)-2-[2-[4-[(2-Chloro-phenyl)phenylMethyl]piperazin-1-yl]ethoxy]aceticAcidDihydrochloride
• 4-(DIPHENYLMETHYL)-1-PIPERAZINEETHANOL DIHYDROCHLORIDE
• 1,4-BIS[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE DIHYDROCHLORIDE
• 4-Chlorobenzophenone
• iperazineacetic acid, 4-[(4- chlorophenyl)phenylMethyl]-
• Cetirizine 3-Chloro IMpurity Dihydrochloride
• 1-(4-Chlorobenzhydryl)piperazine
• Cetirizine-d₄
• CETIRIZINE-D8
• Clemastine fumarate
• Fenarimol
• ROSE BENGAL
• 4,4'-DICHLORO-ALPHA-METHYLBENZHYDROL