Ethyl 5-nitroindole-2-carboxylate Chemical Properties

Melting point:

220-225 °C

Boiling point:

376.52°C (rough estimate)

Density 

1.3240 (rough estimate)

refractive index 

1.5300 (estimate)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

Powder

pka

13.26±0.30(Predicted)

color 

Yellow to brown

Water Solubility 

negligible

CAS DataBase Reference

16732-57-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-41-36

Safety Statements 

24/25-39-26

HazardClass 

IRRITANT

HS Code 

29349990

MSDS

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Ethyl 5-nitroindole-2-carboxylate Usage And Synthesis

Uses

Ethyl 5-Nitroindole-2-carboxylate is used as a reagent in the synthesis of indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. Ethyl 5-Nitroindole-2-carboxylate is also a useful synthetic intermediate in the synthesis of Delavirdine which is a bisheteroarylpiperazine (BHAP) reverse transcriptase inhibitor.

Chemical Properties

yellow to brown powder

Uses

Ethyl 5-Nitroindole-2-carboxylate is used as a reagent in the synthesis of indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. Ethyl 5-Nitroindole-2-carboxylate is also a useful synthetic intermediate in the synthesis of Delavirdine (D230625) which is a bisheteroarylpiperazine (BHAP) reverse transcriptase inhibitor.

Ethyl 5-nitroindole-2-carboxylate(16732-57-3)Related Product Information

• Diethyl nitromalonate
• 5-Nitroindole
• Indole-3-butyric acid
• Indole-3-acetic acid
• Indole-2-carboxylic acid
• Diethyl 1,3-acetonedicarboxylate
• ISOXADIFEN-ETHYL
• Indometacin
• Ethyl cyanoacetate
• Ethylparaben
• RESMETHRIN
• Ethyl acrylate
• Ethyl formate
• Ethyl pyruvate
• Ethanol
• Ethyl acetate
• 5-Nitroindole-2-carboxylic acid
• ETHYL 7-NITROINDOLE-2-CARBOXYLATE