MASTOPARAN X Chemical Properties

Boiling point:

1797.4±65.0 °C(Predicted)

Density 

1?+-.0.06 g/cm3(Predicted)

storage temp. 

-15°C

solubility 

DMF: 25 mg/ml
DMSO: 25 mg/ml
Ethanol: 50 mg/mlPBS (pH 7.2): 1 mg/ml

form 

Lyophilized solid.

pka

13.24±0.46(Predicted)

color 

White to off-white

Safety Information

Safety Statements 

22-24/25

MASTOPARAN X Usage And Synthesis

Uses

Has effects similar to mastoparan; binds with high affinity to calmodulin and inhibits sarcoplasmic reticulum calcium-ATPase

Definition

ChEBI: Mastoparan-V is a member of the class of mastopyrans that is a 14-amino acid polypeptide comprising isoleucyl, asparaginyl, tryptophyl, lysyl, glycyl, isoleucyl, alanyl, alanyl, methionyl, alanyl, lysyl, lysyl, leucyl, and leucinamide residues coupled in sequence. It is the major active component of the venom of the hornet Vespa velutina and causes degranulation of mast cells. It exhibits antimicrobial activity against both Gram-positive and -negative bacteria as well as haemolytic activity on chicken, human and sheep erythrocytes. It has a role as an antibacterial agent. It is a member of mastoparans and a peptidyl amide.

References

[1] CHUN-HSIEN LIN . Structural and biological characterization of mastoparans in the venom of Vespa species in Taiwan[J]. Peptides, 2011, 32 10: Pages 2027-2036. DOI: 10.1016/j.peptides.2011.08.015
[2] DEAN A. MALENCIK  Sonia R A. High affinity binding of the mastoparans by calmodulin[J]. Biochemical and biophysical research communications, 1983, 114 1: Pages 50-56. DOI: 10.1016/0006-291x(83)91592-9
[3] T HIGASHIJIMA  E M R  J Burnier. Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity.[J]. The Journal of Biological Chemistry, 1990, 265 24: 14176-14186.
[4] ANNIELLE MENDES BRITO DA SILVA. Pro-necrotic Activity of Cationic Mastoparan Peptides in Human Glioblastoma Multiforme Cells Via Membranolytic Action.[J]. Molecular Neurobiology, 2018: 5490-5504. DOI: 10.1007/s12035-017-0782-1
[5] XUEQIN ZHAO. The Antimicrobial Peptide Mastoparan X Protects Against Enterohemorrhagic Escherichia coli O157:H7 Infection, Inhibits Inflammation, and Enhances the Intestinal Epithelial Barrier.[J]. Frontiers in Microbiology, 2021: 644887. DOI: 10.3389/fmicb.2021.644887

MASTOPARAN X(72093-22-2)Related Product Information

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