CALYCOSIN Chemical Properties

Melting point:

245～247℃

Boiling point:

536.8±50.0 °C(Predicted)

Density 

1.420±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

solubility 

methanol: soluble1mg/mL, clear, colorless

pka

6.94±0.20(Predicted)

form 

powder

color 

white to light yellow

InChI

InChI=1S/C16H12O5/c1-20-14-5-2-9(6-13(14)18)12-8-21-15-7-10(17)3-4-11(15)16(12)19/h2-8,17-18H,1H3

InChIKey

ZZAJQOPSWWVMBI-UHFFFAOYSA-N

SMILES

C1OC2=CC(O)=CC=C2C(=O)C=1C1=CC=C(OC)C(O)=C1

Safety Information

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

45

RIDADR 

UN 3462 6.1 / PGIII

WGK Germany 

3

HS Code 

2932996560

Hazardous Substances Data

20575-57-9(Hazardous Substances Data)

CALYCOSIN Usage And Synthesis

Definition

Calycosin is an O-methylated isoflavone. It can be isolated from Astragalus membranaceus Bge. var. mongholicus and Trifolium pratense L. Calycosin is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at the 3' position and a methoxy group at the 4' position. It has a role as a metabolite and an antioxidant. It is a member of 7-hydroxyisoflavones and a member of 4'-methoxyisoflavones. It derives from an isoflavone. It is a conjugate acid of a calycosin(1-).

Pharmaceutical Properties

The potential pharmaceutical properties of calycosin in the treatment of tumors, inflammation, stroke, and cardiovascular diseases have gained increasing attention in the recent years. The literature survey showed that calycosin exhibits promising effects for the treatment of several diseases and that these effects may be due to its isoflavonoid and phytoestrogenic properties. The effects of calycosin most likely result from its interaction with the ER receptors on the cell membrane and the modulation of the MAPK signaling pathway.
Through its effect on this pathway, calycosin can regulate several cell activities, such as apoptosis and angiogenesis, which enables its therapeutic functions. 

Uses

Calycosin is a known antioxidant that prevent redox imbalance in organisms. Also, it possesses anti-tumor, anti-inflammation and osteogenic properties; Useful as a therapeutic reagent for bone loss-associated diseases.

Definition

ChEBI: Calycosin is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at the 3' position and a methoxy group at the 4' position. It has a role as a metabolite and an antioxidant. It is a member of 7-hydroxyisoflavones and a member of 4'-methoxyisoflavones. It is functionally related to an isoflavone. It is a conjugate acid of a calycosin(1-).

CALYCOSIN(20575-57-9)Related Product Information

• Verbascoside
• CALYCOSIN 7-O-GLUCOSIDE
• CALYCOSIN
• 5-HYDROXYDEQUELIN
• Isoflavone
• PSEUDOBAPTIGENIN-7-GLUCOSIDE
• 4H-1-Benzopyran-4-one, 3-(3,4-dimethoxyphenyl)-7-methoxy-
• 6-HYDROXY-7-METHOXY-3',4'-METHYLENEDIOXYISOFLAVONE
• OROBOL 7,4'-DIMETHYL ETHER
• PSEUDOBAPTIGENIN
• 3',4'-DIMETHOXY-7-HYDROXYISOFLAVONE
• PRATENSEIN
• FUJIKINETIN
• Calycosin-O-β-D-glucopyranoside
• CALYCOSIN(RG)
• AKOS 212-61
• DEMETHYLACICERONE
• POMIFERIN-3',4'-DIMETHYL ETHER