3-Bromoquinoline Chemical Properties

Melting point:

13-15 °C (lit.)

Boiling point:

274-276 °C (lit.)

Density 

1.533 g/mL at 25 °C (lit.)

vapor pressure 

0.196Pa at 25℃

refractive index 

n20/D 1.664(lit.)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

2.69(at 25℃)

form 

Liquid

color 

Clear colorless to yellow

Water Solubility 

103mg/L at 25℃

BRN 

112939

InChIKey

ZGIKWINFUGEQEO-UHFFFAOYSA-N

LogP

3.03

CAS DataBase Reference

5332-24-1(CAS DataBase Reference)

NIST Chemistry Reference

Quinoline, 3-bromo-(5332-24-1)

EPA Substance Registry System

Quinoline, 3-bromo- (5332-24-1)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

RIDADR 

UN2810

WGK Germany 

3

TSCA 

Yes

HS Code 

29334900

MSDS

• Language:English Provider:3-Bromoquinoline
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
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3-Bromoquinoline Usage And Synthesis

Bromoquinoline

There are seven position isomers with the main properties are as follows:

Application and synthesis method

3-Bromoquinoline can have action with mixed acid to generate 3-bromo-5-nitroquinoline, followed by heating with potassium permanganate to be oxidized to 5-bromo-2, 3-pyridine dicarboxylic acid.
6-bromo-quinoline can be heated together nitric acid to generate 6-bromo-8-nitro-quinoline, followed by reaction with potassium permanganate to be oxidized into 2, 3-pyridinedicarboxylic acid.
2-bromo-quinoline can be manufactured through the reaction between 2-hydroxyquinoline and phosphorus pentabromide
3-bromo-quinoline can be obtained through heating the quinoline perbromide at 180 ° C.
4-bromoquinoline can be obtained through either the heating reaction between 4-hydroxyquinoline and phosphorus pentabromide or by the diazotization reaction of 4-aminoquinoline.
5-bromo-quinoline can be obtained from the heating reaction between m-bromo aniline, glycerol, m-bromonitrobenzene and concentrated sulfuric acid, or through the diazotization reaction of 5-amino-quinoline.
6-bromo-quinoline can be obtained through the heating reaction between p-bromoaniline, glycerol, concentrated sulfuric acid and p-bromo-nitrobenzene.
7-bromoquinoline can be obtained through the diazotization of 7-aminoquinoline.
8-bromo-quinoline can be obtained through the heating of o-bromo aniline, glycerol, concentrated sulfuric acid and o-bromo-nitrobenzene in the heating system.
Purposes: as organic synthesis reagents.

Uses

For pharmaceuticals
Medicine, pesticide intermediates

Chemical Properties

colorless to light yellow liquid

Synthesis Reference(s)

The Journal of Organic Chemistry, 27, p. 1318, 1962 DOI: 10.1021/jo01051a047

General Description

3-Bromoquinoline undergoes bromine-magnesium exchange reaction with lithium tributylmagnesate in toluene at -10°C, which is quenched by various electrophiles to yield functionalized quinolines.

Flammability and Explosibility

Not classified

3-Bromoquinoline(5332-24-1)Related Product Information

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