Clenbuterol hydrochloride Chemical Properties

Melting point:

174-175.5°C

Flash point:

9℃

storage temp. 

2-8°C

solubility 

Soluble in water and in ethanol (96 per cent), slightly soluble in acetone.

Merck 

14,2347

InChIKey

OPXKTCUYRHXSBK-UHFFFAOYSA-N

CAS DataBase Reference

21898-19-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

T,F

Risk Statements 

25-39/23/24/25-23/24/25-11

Safety Statements 

22-36/37/39-45-36/37-16

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

DN3180000

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29221990

Toxicity

LD50 in mice, rats, guinea pigs (mg/kg): 176, 315, 67.1 orally; 27.6, 35.3, 12.6 i.v. (Ueberberg)

MSDS

• Language:English Provider:SigmaAldrich

Clenbuterol hydrochloride Usage And Synthesis

Selective β2 adrenergic receptor agonist

Clenbuterol-hydrochloride exhibits as white crystalline powder. Its chemical name is hydroxymethyl tert-butanol adrenaline or 2-[(tert-butylamino) methyl]-4-amino-3, 5-dichlorobenzene methoxide salt. It is a kind of potent, selectively β2 adrenergic receptor agonists and can be used for relaxing bronchial smooth muscle for the treatment of bronchial asthma, asthmatic bronchitis and bronchitis with emphysema.
The main component of "Shouroujing" is clenbuterol. Because of its certain effects on animals such as promoting the protein synthesis of muscle, promoting lipid decomposition and reducing fat accumulation, it can cause the relative increase of lean meat content of the animal and thus improving livestock quality. Owing to this property, we also referred it as "growth promoters" and "nutrition re-dispersing agent."
In the early 1960s, it was found that it can promote the animal growth; In the 1970s, the United States had introduced it into poultry production and it has become the world's most widely used β-stimulants. However, as the substance has a strong thermal stability and biochemical stability, after animal consumption, it is capable of forming residue in organs and tissues. Upon eating pork containing clenbuterol, people can get poisoning symptoms. Thus, many countries in the world had sooner or later banned the application of β-agonists in animal husbandry. Many countries have developed detection method for monitoring β-agonists residues and clenbuterol of the feed. In 1997, our government had also banned clenbuterol for being used as feed additives.
Precautions: a minority of patients may get adverse reactions such as mild heart palpitations, tremor, and dizziness with the symptoms gradually disappear in general after the medication. Patients of hyperthyroidism, tachycardia or hypertension should be taken with caution.
Preparation: ordinary tablets, aerosols, suppositories, films agent and patches.

The above information is edited by the Chemicalbook of Dai Xiongfeng.

Uses

Clenbuterol hydrochloride can be used for the prevention and treatment of bronchial asthma, chronic bronchitis, emphysema-accompanied bronchial spasms caused by bronchitis.Clenbuterol hydrochloride is a kind of β2-adrenergic receptor agonists and can be used as bronchodilators.

Category toxic

substances

Toxicity grading

highly toxic

Acute toxicity

intraperitoneal-mouse TDL0: 2 mg/kg

Flammability and hazard characteristics

flammable with combustion cause its decomposition into toxic chloride and nitrogen oxide gases

Storage properties, warehouse

cold, ventilated and dry; store it separately from food raw materials

Extinguishing media

Water, carbon dioxide, dry, sandy soil.

Chemical Properties

Colourless Microcyrstalline Powder

Uses

Bronchodilatator;Beta adrenergic agonist

Uses

Substituted phenylethanolamine with β2 sympathomimetic activity. Bronchodilator. A β-Agonist which can be used as a growth promoter in farm animals.

Uses

decongestant bronchodilator

Uses

Antiasthmatic

Uses

Substituted phenylethanolamine with 2 sympathomimetic activity. Bronchodilator

Definition

Clenbuterol hydrochloride is a hydrochloride that is the monohydrochloride salt of clenbuterol.

Veterinary Drugs and Treatments

Clenbuterol is approved for use in horses as a bronchodilator in the management of airway obstruction, such as recurrent airway obstruction (RAO; formerly COPD).
It has been used as a partitioning agent in food producing animals, but its use for this purpose is banned in the USA as relay toxicity in humans has been documented.

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