C-(3,4-DIMETHOXY-BICYCLO[4.2.0]OCTA-1(6),2,4-TRIEN-7-YL)-METHYLAMINE Chemical Properties

Boiling point:

309℃

Density 

1.113

Flash point:

153℃

storage temp. 

2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

9.70±0.29(Predicted)

color 

Off-White to Pale

C-(3,4-DIMETHOXY-BICYCLO[4.2.0]OCTA-1(6),2,4-TRIEN-7-YL)-METHYLAMINE Usage And Synthesis

Uses

4,5-Dimethoxy-1-(aminomethyl)benzocyclobutane is used in the synthesis of ent-Ivabradine Hydrochloride (I940505), which is a selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Also an antianginal.

C-(3,4-DIMETHOXY-BICYCLO[4.2.0]OCTA-1(6),2,4-TRIEN-7-YL)-METHYLAMINE(73344-75-9)Related Product Information

• Ivabradine hydrochloride
• INDEX NAME NOT YET ASSIGNED
• 3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)-N-(((S)-3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)-N-methylpropan-1-amine oxide
• 3-[3-[[[(7S)-3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]MethylaMino]propyl]-1,3-dihydro-7,8-diMethoxy-H-3-benzazepin-2-one
• 7-DeMethyl Ivabradine
• 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
• N-DeMethyl Ivabradine Hydrochloride
• 3,3'-(propane-1,3-diyl)bis(7,8-dimethoxy-1,3-dihydro-2H-benzo[d]azepin-2-one)
• (3,4-Dimethoxyphenyl)acetic acid
• Hydroxy Ivabradine
• N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide
• 8-DeMethyl Ivabradine
• 3-(3-Chloropropyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one
• 3,3'-(propane-1,3-diyl)bis(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one)
• (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one
• (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride
• Ivabradine Impurity 70
• 1204612-29-2