TERT-BUTYL 1-OXO-2,7-DIAZASPIRO[4.5]DECANE-7-CARBOXYLATE Chemical Properties

Boiling point:

425℃

Density 

1.15

Flash point:

211℃

storage temp. 

2-8°C

pka

15.97±0.20(Predicted)

Appearance

White to off-white Solid

Safety Information

HS Code 

2933998090

TERT-BUTYL 1-OXO-2,7-DIAZASPIRO[4.5]DECANE-7-CARBOXYLATE Usage And Synthesis

Synthesis

Preparation of Example 44: tert-butyl 1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate (P44) was synthesized as follows: 2,7-diazaspiro[4.5]decan-1-one hydrochloride (600 mg, 3.15 mmol) was dissolved in 30 mL of dichloromethane (DCM). To this solution, triethylamine (TEA, 1.98 mL, 14.18 mmol) and di-tert-butyl dicarbonate (Boc2O, 895 mg, 4.10 mmol) were added sequentially. The reaction mixture was stirred at room temperature for 4 hours. After completion of the reaction, it was quenched by addition of water and the organic and aqueous layers were separated. The organic layer was washed with aqueous ammonium chloride (NH4Cl), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent to afford the target product tert-butyl 1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate (P44, 830 mg, quantitative yield) as a colorless oil. Mass spectrum (ESI) m/z: 255.2 [M + H]+.

References

[1] Patent: WO2016/42451, 2016, A1. Location in patent: Page/Page column 84

TERT-BUTYL 1-OXO-2,7-DIAZASPIRO[4.5]DECANE-7-CARBOXYLATE(923009-50-1)Related Product Information

• 1-Oxa-4,8-diazaspiro[5.5]undecan-8-carboxylic acid tert-butyl ester
• 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate
• 3-Azabicyclo[3.1.0]hexane-3,6-dicarboxylic acid 3-tert-butyl ester
• 7-Boc-1,7-diaza-spiro[4.4]nonane
• Tert-butyl 2,6-diazaspiro[3.4]octane-6-carboxylate
• 1-BENZYL-OCTAHYDRO-PYRROLO[3,4-B]PYRROLE
• 2-(3-(TERT-BUTOXYCARBONYL)-3-AZASPIRO[5.5]UNDECAN-9-YL)ACETIC ACID
• Carbamic acid, 3-azabicyclo[3.1.0]hex-1-yl-, 1,1-dimethylethyl ester (9CI)
• 4-OXO-HEXAHYDRO-CYCLOPENTA[C]PYRROLE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
• BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER
• Tert-butyl 1,7-diazaspiro[4,4]nonane-1-carboxylate
• Tert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylate
• benzyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
• 2S-7-Aza-bicyclo[2.2.1]heptane-2,7-dicarboxylic acid 7-tert-butyl ester
• 7-(TERT-BUTOXYCARBONYL)-1-OXA-2,7-DIAZASPIRO[4.4]NON-2-ENE-3-CARBOXYLIC ACID
• tert-butyl 2-formylpropan-2-ylcarbamate
• H2N-PEG1-CH2COOtBu
• TERT-BUTYL 3-FLUORO-4-OXOPIPERIDINE-1-CARBOXYLATE