GLYX 13 Chemical Properties

Boiling point:

844.2±65.0 °C(Predicted)

Density 

1.370±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility 

DMF: 25 mg/ml; DMSO: 15 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 5 mg/ml

form 

powder

pka

12.26±0.45(Predicted)

color 

white to tan

Water Solubility 

Soluble to 2 mg/ml in water

Safety Information

WGK Germany 

3

GLYX 13 Usage And Synthesis

Uses

Rapastinel is a novel antidepressant drug approved as an adjunctive therapy for the treatment of treatment-resistant major depressive disorder. It is a centrally active, intravenously administered (non-orally active) amidated tetrapeptide (Thr-Pro-Pro-Thr-NH2) that acts as a selective, weak partial agonist (mixed antagonist/agonist) of an allosteric site at the glycine site of the NMDA receptor complex (Emax ≈ 25%).The drug is a rapid-acting and long-lasting antidepressant as well as robust cognitive enhancer by virtue of its ability to both inhibit and enhance NMDA receptor-mediated signal transduction.

Uses

GLYX-13 is a long lasting and rapid acting antidepressant. Investigational drug for the treatment of depressive disoder.

Uses

GLYX-13 trifluoroacetate has been used as an activator of NMDA (N-methyl-D-aspartate) receptor.

Biochem/physiol Actions

GLYX-13 is a glycine-site functional partial agonist (GFPA) selective modulator of the NMDA receptor (NMDAR). It is a brain penetrable tetrapeptide which acts as a positive allosteric modulator of the NMDA receptor, acting via the glycine site. GLYX-13 has been found to be a cognitive enhancer in learning models and is currently in clinical trials as an antidepressant.

storage

Store at -20°C

GLYX 13(117928-94-6)Related Product Information

• Linezolid
• Teriparatide acetate
• RESIQUIMOD