2,7-Dihydroxy-9-fluorenone Chemical Properties

Melting point:

338 °C

Boiling point:

444.5±20.0 °C(Predicted)

Density 

1.497±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

powder to crystal

pka

8.87±0.20(Predicted)

color 

Light yellow to Brown

InChI

InChI=1S/C13H8O3/c14-7-1-3-9-10-4-2-8(15)6-12(10)13(16)11(9)5-7/h1-6,14-15H

InChIKey

CWHPQXRTQSNTRR-UHFFFAOYSA-N

SMILES

C1(=O)C2=C(C=CC(O)=C2)C2=C1C=C(O)C=C2

CAS DataBase Reference

42523-29-5(CAS DataBase Reference)

Safety Information

HS Code 

2914.50.3000

2,7-Dihydroxy-9-fluorenone Usage And Synthesis

Chemical Properties

Dark red crystal or powder

Uses

2,7-dihydroxy-9-fluorenone is used as organic intermediates.

Synthesis

Methyl 4,4'-dihydroxy-[1,1'-biphenyl]-2-carboxylate (50 g, 0.20 mol) was used as a raw material and mixed with ZnCl2 (50 g, 0.37 mol) and polyphosphoric acid (PPA, 33 mL). The reaction mixture was stirred at 110-120 °C for 2 hours. Upon completion of the reaction, it was cooled to room temperature and water (500 mL) was slowly added to precipitate the product. The precipitate was collected by filtration and dried to give 40 g of reddish brown crystalline powder (2,7-dihydroxy-9-fluorenone). The yield was 95%; melting point 336-337°C (literature value 338°C [24]); IR (KBr) ν (cm^-1): 3388.9, 3360.6 (OH), 1700.7 (C=O); ESI-MS (m/z): 211.0 [M+H]^+, molecular formula C13H8O3 (molecular weight 212.0); 1H- NMR (300MHz, DMSO-d6) δ (ppm): 9.89 (s, 2H), 7.37 (d, J=4.8Hz, 2H), 6.90 (dd, J=4.9,2.4Hz, 2H), 6.86 (d, J=2.4Hz, 2H).

References

[1] Molecules, 2015, vol. 20, # 12, p. 21458 - 21463
[2] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 17, p. 4601 - 4611

2,7-Dihydroxy-9-fluorenone(42523-29-5)Related Product Information

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• Triclosan
• Chrysin
• Solvent Red 43
• Phenylfluorone
• 9-Fluorenone
• 3-Diethylaminophenol
• 1,3-Dihydroxyacetone
• 1-Hydroxyethylidene-1,1-diphosphonic acid
• Fluorene
• Tilorone dihydrochloride
• CHRYSAZIN(RG)
• DIHYDROXY BENZALDEHYDE
• 2,7-Dihydroxy-9-fluorenone
• 2,7-DIMETHOXY-9H-FLUOREN-9-ONE
• 2,7-bis[2-(dimethylamino)ethoxy]-9H-fluoren-9-one dihydrochloride
• 2,7-DIETHOXY-9H-FLUOREN-9-ONE
• 9-hydroxybenfluron