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BMS 833923

Basic information Safety Supplier Related

BMS 833923 Basic information

Product Name:
BMS 833923
Synonyms:
  • BMS 833923
  • XL 139
  • XL139
  • XL-139
  • BMS-833923 (XL-139)
  • N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide
  • Benzamide, N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]-
  • BMS 833923 N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide
CAS:
1059734-66-5
MF:
C30H27N5O
MW:
473.57
Product Categories:
  • Inhibitors
Mol File:
1059734-66-5.mol
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BMS 833923 Chemical Properties

Density 
1.252±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥47.4 mg/mL in DMSO; insoluble in H2O; ≥5.14 mg/mL in EtOH with gentle warming and ultrasonic
form 
solid
pka
13.42±0.70(Predicted)
color 
Light yellow to yellow
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BMS 833923 Usage And Synthesis

Description

Smoothened (Smo) is a cell surface receptor that, with Patched, mediates sonic hedgehog (Shh) signaling to regulate gene expression through the Gli transcription factors. BMS 833923 is an orally bioavailable inhibitor of Smo. It blocks binding of BODIPY cyclopamine (IC50 = 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC50s = 6-35 nM). BMS 833923 robustly inhibits Shh pathway activity and prevents tumor growth in medulloblastoma and pancreatic carcinoma xenograft models.

Uses

BMS 833923 is an antagonist of smoothened, a key hedgehog (Hh) pathway regulator.

BMS 833923Supplier

Beijing LAL Pharmaceutical Co., Ltd. Gold
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Shanghai Boyle Chemical Co., Ltd.
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Dalian Meilun Biotech Co., Ltd.
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NCE Biomedical Co.,Ltd.
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