2',7-DIHYDROXY-4'-METHOXYISOFLAVAN CAS#: 56701-24-7

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2',7-DIHYDROXY-4'-METHOXYISOFLAVAN

Basic information Safety Supplier Related

2',7-DIHYDROXY-4'-METHOXYISOFLAVAN Basic information

Product Name:

2',7-DIHYDROXY-4'-METHOXYISOFLAVAN

Synonyms:

VESTITOL
2',7-DIHYDROXY-4'-METHOXYISOFLAVAN
3-(2-Hydroxy-4-methoxyphenyl)-7-chromanol
3-(2-Hydroxy-4-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-7-ol
3-(2-Hydroxy-4-methoxyphenyl)chroman-7-ol
3,4-Dihydro-3-(2-hydroxy-4-methoxyphenyl)-2H-1-benzopyran-7-ol
2H-1-Benzopyran-7-ol, 3,4-dihydro-3-(2-hydroxy-4-methoxyphenyl)-
VESTITOL(RG)(PLEASE CALL)

CAS:

56701-24-7

MF:

C16H16O4

MW:

272.3

Product Categories:

Iso-Flavones

Mol File:

56701-24-7.mol

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2',7-DIHYDROXY-4'-METHOXYISOFLAVAN Chemical Properties

Melting point:: 172-179℃
Boiling point:: 418.5±45.0 °C(Predicted)
Density: 1.282±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO: 2mg/mL, clear
form: powder
pka: 9.53±0.40(Predicted)
color: white to beige

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2',7-DIHYDROXY-4'-METHOXYISOFLAVAN Usage And Synthesis

Uses

Vestitol is the compound isolated from leaves of Trifolium arvense[1].

Definition

ChEBI: Vestitol is a member of the class of hydroxyisoflavans that is isoflavan substituted by hydroxy groups at positions 7 and 2' and a methoxy group at position 4'. Isolated from Glycyrrhiza uralensis, it exhibits anti-inflammatory activity. It has a role as an anti-inflammatory agent, a plant metabolite and a phytoalexin. It is an aromatic ether, a member of hydroxyisoflavans and a methoxyisoflavan.

Biological Activity

Hydroxyisoflavan isolated from Cuban and Brazilian red propolis th at exhibits potent anti-inflammatory, anti-viral, and antiparasitic activities.

(±)-Vestitol is a hydroxyisoflavan isolated from Cuban and Brazilian red propolis, licorice root and other sources th at exhibits potent anti-inflammatory, anti-viral, and antiparasitic activities. Apparently Vestitol inhibits release of the chemokines CXCL1/KC and CXCL2/MIP-2 from macrophages. Vestitol strongly inhibits Chikungunya virus infection. Vestitol exhibits anti-trypanosomal activity against T. brucei and T. congolense (EC50 3.86 and 4.36 μg/ml).

References

[1] John L. Ingham, et al. Notizen: Isoflavonoid Phytoalexins from Leaves of Trifolium arvense.

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