Ethyl 4-hydroxypiperidine-1-carboxylate Chemical Properties

Boiling point:

120-130 °C(Press: 0.098 Torr)

Density 

1.12

refractive index 

1.4802

storage temp. 

Inert atmosphere,Room Temperature

form 

clear liquid

pka

14.80±0.20(Predicted)

color 

Colorless to Light yellow to Light orange

InChI

InChI=1S/C8H15NO3/c1-2-12-8(11)9-5-3-7(10)4-6-9/h7,10H,2-6H2,1H3

InChIKey

QABJNOSERNVHDY-UHFFFAOYSA-N

SMILES

N1(C(OCC)=O)CCC(O)CC1

CAS DataBase Reference

65214-82-6(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

HS Code 

29333990

Ethyl 4-hydroxypiperidine-1-carboxylate Usage And Synthesis

Chemical Properties

Colorless liquid

Uses

Ethyl 4-hydroxypethidine-1-carboxylate is mainly used as a pharmaceutical intermediate and a raw material for organic matter. It can be used in the synthesis of antihistamines, antipsychotics, antidepressants, and various pesticides. As an intermediate, the compound can also produce fungicides and insecticides. It can be used as a raw material for synthetic surfactants, flavors, and fragrances.

Preparation

Add triethylamine (1.5 equivalent) and ethyl chlorine 4-hydroxypiperidine-1-carboxylate (1.2 equivalent) to the dichloromethane solution of 4-hydroxypiperidine (1.0 equivalent) at 0 °C. Stir the mixture at 0 °C for 30 min. The reaction mixture is then poured into water and extracted with methylene chloride. Wash organic extracts with water and salt water. The compound is placed on sodium sulfate to dry. Finally, the organic extract is concentrated under reduced pressure to obtainEthyl 4-hydroxypiperidine-1-carboxylate.

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