1H-Isoindole-1,3(2H)-dione, 2-[1-(3-ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethyl]- Chemical Properties

Boiling point:

673.6±55.0 °C(Predicted)

Density 

1.383±0.06 g/cm3(Predicted)

pka

-0.76±0.20(Predicted)

InChI

InChI=1S/C20H22N2O6S/c1-4-28-17-10-12(8-9-16(17)27-2)15(11-29(3,25)26)22-19(23)13-6-5-7-14(21)18(13)20(22)24/h5-10,15H,4,11,21H2,1-3H3

InChIKey

BHJUWEUNUCJYER-UHFFFAOYSA-N

SMILES

C1(=O)C2=C(C(N)=CC=C2)C(=O)N1C(C1=CC=C(OC)C(OCC)=C1)CS(C)(=O)=O

1H-Isoindole-1,3(2H)-dione, 2-[1-(3-ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethyl]- Usage And Synthesis

Uses

4-Amino-2-[1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1H-isoindole-1,3(2H)-dione is used in the apremilast acetylamino analogs preparation as oral PDE4 and TNF-α inhibitors.

1H-Isoindole-1,3(2H)-dione, 2-[1-(3-ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethyl]-(253168-83-1)Related Product Information

• Apremilast Impurity 84
• N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide
• 3-Ethoxy-4-methoxy benzonitrile
• 3-Nitrophthalic acid
• Apremilast Impurity 19
• Apremilast Impurity 15
• Apremilast impurity 18
• 4-acetamidophthalic acid
• 1-Methyl-3-nitrophthalate
• 4-Nitrophthalic acid
• Apremilast Impurity 4
• BenzeneMethanaMine, 4-ethoxy-3-Methoxy-a-[(Methylsulfonyl)Methyl]-
• Apremilast-d8
• Apremilast Impurity 25
• 1-(3,4-Diethoxyphenyl)-2-(methylsulfonyl)ethan-1-amine
• Apremilast Impurity 28
• (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt
• Apremilast Impurity 34