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Sofosbuvir metabolites GS566500

Basic information Safety Supplier Related

Sofosbuvir metabolites GS566500 Basic information

Product Name:
Sofosbuvir metabolites GS566500
Synonyms:
  • Sofosbuvir metabolites GS566500
  • GS-566500
  • N-[(2'R)-2'-Deoxy-2'-fluoro-2'-methyl-5'-uridylyl]-L-alanine
  • (2S)-2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)amino)propanoic acid
  • Sofosbuvir Impurity 49 (GS-566500)
  • (2S)-2-(((((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)amino)propanoic Acid Ammonium Salt
  • O-Desisopropyl O-Desphenyl Sofosbuvir Ammonium Salt
  • (2S)-2-(((((2R,3R,4R,5S)-5-((R)-2,6-dioxo-1,2,3,6-tetrahydropyridin-3-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)amino)propanoic acid
CAS:
1233335-78-8
MF:
C13H19FN3O9P
MW:
411.28
Mol File:
1233335-78-8.mol
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Sofosbuvir metabolites GS566500 Chemical Properties

Density 
1?+-.0.1 g/cm3(Predicted)
solubility 
DMSO (Slightly), Methanol (Very Slightly, Heated)
form 
Solid
pka
2.66±0.50(Predicted)
color 
Off-White to Pale Beige
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Sofosbuvir metabolites GS566500 Usage And Synthesis

Uses

PSI 352707 Ammonium Salt is a metabolite of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-a-fluoro-b-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C.

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