6-CHLORO-3,4-PYRIDINEDIAMINE Chemical Properties

Melting point:

162 °C

Boiling point:

409.3±40.0 °C(Predicted)

Density 

1.447±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

powder

pka

4.79±0.42(Predicted)

color 

Yellow

InChI

InChI=1S/C5H6ClN3/c6-5-1-3(7)4(8)2-9-5/h1-2H,8H2,(H2,7,9)

InChIKey

OQRXBXNATIHDQO-UHFFFAOYSA-N

SMILES

C1=NC(Cl)=CC(N)=C1N

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HS Code 

29333990

6-CHLORO-3,4-PYRIDINEDIAMINE Usage And Synthesis

Application

3,4-Diamino-6-chloropyridine is a heterocyclic organic compound that can be used as a pharmaceutical intermediate.

Chemical Properties

Pink solid

Synthesis

Step 1: 2-Chloro-5-nitropyridin-4-amine (4.50 g, 25.93 mmol) was dissolved in ethyl acetate (100 mL) and nickel ruanne (0.45 g) was added. The reaction mixture was stirred at room temperature for 2 hours in a hydrogen atmosphere. After completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give the crude 6-chloropyridine-3,4-diamine (4.00 g, about 100% yield) as a yellow oil. Mass spectrometry (ESI) analysis showed: m/z = 144.3 [M + 1]+.

References

[1] Patent: WO2013/92940, 2013, A1. Location in patent: Page/Page column 54
[2] Patent: EP2017277, 2009, A1. Location in patent: Page/Page column 29

6-CHLORO-3,4-PYRIDINEDIAMINE(89182-17-2)Related Product Information

• 4-Aminopyridine
• 3-Aminopyridine
• 3,4-Diaminopyridine
• 2,6-DIAMINO-4-CHLOROPYRIDINE
• 2-Chloro-3,4-pyridinediamine
• 2-Chloro-5-nitropyridin-4-amine
• 2,3-Diamino-4-chloropyridine
• 5-CHLORO-2,3-DIAMINOPYRIDINE
• 6-chloropyridine-3,4-diamine hydrochloride
• 2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE
• 6-CHLORO-3,4-PYRIDINEDIAMINE
• tert-butyl 2-chloro-5-nitropyridin-4-ylcarbamate
• (2-CHLORO-5-NITRO-PYRIDIN-4-YL)-ETHYL-AMINE
• 3,4-DIAMINO-2,6-DICHLOROPYRIDINE, DIHYDROCHLORIDE
• 2,6-DICHLOROPYRIDINE-3,4-DIAMINE
• 2,3-DIAMINO-6-CHLOROPYRIDINE
• 2,4-AMINO-6-CHLOROPYRIDINE
• 2,6-DICHLORO-3,5-DINITRO-4-AMINOPYRIDINE