SBI-0640756
SBI-0640756 Basic information
- Product Name:
- SBI-0640756
- Synonyms:
-
- SBI-0640756
- (E)-6-chloro-3-(3-(5-fluoropyridin-3-yl)acryloyl)-4-phenylquinolin-2(1H)-one
- CS-2838
- SBI 756
- SBI-0640756;SBI 0640756;SBI0640756;SBI 756;SBI756;SBI-756
- SBI756
- SBI-756
- 2(1H)-Quinolinone,6-chloro-3-[(2E)-3-(5-fluoro-3-pyridinyl)-1-oxo-2-propen-1-yl]-4-phenyl-
- CAS:
- 1821280-29-8
- MF:
- C23H14ClFN2O2
- MW:
- 0
- Mol File:
- Mol File
SBI-0640756 Chemical Properties
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO : ≥ 26 mg/mL (64.23 mM)
- form
- Solid
- color
- Light yellow to yellow
SBI-0640756 Usage And Synthesis
Uses
SBI-0640756 (SBI-756) is an inhibitor of eIF4G1 and disrupts the eIF4F complex.
Biological Activity
SBI-0640756 is a potent inhibitor of eIF4G1 th at disrupts the eIF4F complex assembly independently of mTOR. SBI-0640756 potently inhibits growth of BRAF-resistant and BRAF-independent melanomas including NRAS- and NF1-mutant melanomas. SBI-0640756 exhibits low toxicity against nontransformed fibroblasts. SBI-0640756 also suppressed AKT and NF-kB signaling.
in vivo
SBI-0640756 (SBI-756) (0.5 mg/kg, i.p.) delays tumor onset and reduces tumor incidence by 50% in NrasQ61K/Ink4a–/– genetic model. SBI-0640756 (SBI-756) (1 mg/kg, 2 times per week, i.p.) in combination with BRAF inhibitor potently suppresses growth of established tumors and does not resume tumor growth in immunodeficient mice bearing A375 tumors[1].
IC 50
eIF4
References
[1] Feng Y et al. SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex. Cancer Res, 2015 Dec 15, 75(24):5211-8. DOI:10.1158/0008-5472.CAN-15-0885
SBI-0640756Supplier
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- sales@boylechem.com
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- 021-58955995
- sales@medchemexpress.cn
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- 021-52996696，15000506266 15000506266
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- 021-61350663 13052117465
- sales@zehanbiopharma.com
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- 18-086626237 18086626237
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