Basic information Safety Supplier Related

NSC781406

Basic information Safety Supplier Related

NSC781406 Basic information

Product Name:
NSC781406
Synonyms:
  • NSC781406
  • NSC781406;NSC-781406;NSC 781406
  • NSC-781406;NSC 781406
  • Benzenesulfonamide, 2,4-difluoro-N-[2-methoxy-5-[4-[3-[4-(methylsulfonyl)-1-piperazinyl]-1-propyn-1-yl]-6-quinolinyl]-3-pyridinyl]-
  • NSC781406,Phosphoinositide 3-kinase,NSC 781406,NSC-781406,PI3K,Mammalian target of Rapamycin,Inhibitor,inhibit,mTOR
  • 2,4-difluoro-N-[2-methoxy-5-[4-[3-[4-(methylsulfonyl)-1-piperazinyl]-1-propyn-1-yl]-6-quinolinyl]-3-pyridinyl]-benzenesulfonamide
CAS:
1676893-24-5
MF:
C29H27F2N5O5S2
MW:
627.68
Mol File:
1676893-24-5.mol
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NSC781406 Chemical Properties

Boiling point:
775.1±70.0 °C(Predicted)
Density 
1.52±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 10mg/mL; DMSO: 20mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL
form 
A solid
pka
6.23±0.40(Predicted)
color 
White to off-white
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NSC781406 Usage And Synthesis

Description

NSC 781406 is a dual inhibitor of PI3K and mammalian target of rapamycin (mTOR; IC50s = 2.0, 9.4, 2.7, 14, and 5.4 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR, respectively). It inhibits cell growth in the NCI-60 panel of cancer cell lines (mean GI50 = 65 nM). NSC 781406 (30 mg/kg) reduces tumor volume in a BEL-7404 hepatic cancer mouse xenograft model.

NSC781406Supplier

Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
MedChemexpress LLC
Tel
021-58955995
Email
sales@medchemexpress.cn
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
YouCoChem (Beijing) Chemical Technology Co., Ltd.
Tel
18800159827
Email
youcochem@163.com
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Email
2853530910@QQ.com
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NSC781406(1676893-24-5)Related Product Information