NSC781406 Chemical Properties

Boiling point:

775.1±70.0 °C(Predicted)

Density 

1.52±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 10mg/mL; DMSO: 20mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL

form 

A solid

pka

6.23±0.40(Predicted)

color 

White to off-white

NSC781406 Usage And Synthesis

Description

NSC 781406 is a dual inhibitor of PI3K and mammalian target of rapamycin (mTOR; IC₅₀s = 2.0, 9.4, 2.7, 14, and 5.4 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR, respectively). It inhibits cell growth in the NCI-60 panel of cancer cell lines (mean GI₅₀ = 65 nM). NSC 781406 (30 mg/kg) reduces tumor volume in a BEL-7404 hepatic cancer mouse xenograft model.

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