SR-18292
SR-18292 Basic information
- Product Name:
- SR-18292
- Synonyms:
-
- SR-18292
- SR-18292; SR 18292; SR18292
- SR 18292;SR18292
- 2-Propanol, 1-[(1,1-dimethylethyl)[(4-methylphenyl)methyl]amino]-3-(1H-indol-4-yloxy)-
- 1-((1H-Indol-4-yl)oxy)-3-(tert-butyl(4-methylbenzyl)amino)propan-2-ol
- PPARγ coactivator-1α,PGC-1α,Autophagy,SR18292,SR-18292,Inhibitor,inhibit
- SR-18292, 10 mM in DMSO
- SR-18292 ，S8528
- CAS:
- 2095432-55-4
- MF:
- C23H30N2O2
- MW:
- 366.5
- Mol File:
- 2095432-55-4.mol
SR-18292 Chemical Properties
- Boiling point:
- 553.6±50.0 °C(Predicted)
- Density
- 1.132±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml; Ethanol: 10 mg/ml
- form
- A crystalline solid
- pka
- 13.90±0.20(Predicted)
- color
- White to light brown
SR-18292 Usage And Synthesis
Uses
SR 18292 is a novel selective inhibitor of PGC-1alpha Gluconeogenic Activity.
Biological Activity
SR-18292 is a potent and specific inhibitor of hepatic gluconeogenesis via increased acetylation of PGC-1α and suppression of gluconeogenic gene expression. SR-18292 reduces blood glucose and increases hepatic insulin sensitivity in mouse models of T2D.
in vivo
SR-18292 reduces fasting blood glucose, increases hepatic insulin sensitivity and improves glucose homeostasis in diabetic mice. The high fat diet (HFD) fed mice, a dietary model of obesity and T2D, are treated with SR-18292 (45mg/kg) via I.P. injection for 3 consecutive days and again on day 4 before measuring fasting blood glucose. Strikingly, mice that are treated with SR-18292 have significantly lower levels of fasting blood glucose concentrations compared to matched vehicle-treated control mice. The induction of gluconeogenic gene expression is a regulatory component of the response to fasting. Importantly, gluconeogenic gene expression, specifically that of Pck1, is inhibited in livers isolated from mice treated with SR-18292[1].
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