Basic information Safety Supplier Related

SRPK inhibitor

Basic information Safety Supplier Related

SRPK inhibitor Basic information

Product Name:
SRPK inhibitor
Synonyms:
  • 4-Pyridinecarboxamide, N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]-
  • N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide SRPIN 340
  • SRPK inhibitor N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide
  • SRPIN 340
  • SRPIN340
  • SRPIN-340
  • SRPK inhibitor
  • N-(2-(piperidin-1-yl)-5-(trifluoroMethyl)phenyl)isonicotinaMide
CAS:
218156-96-8
MF:
C18H18F3N3O
MW:
349.35
Product Categories:
  • Inhibitors
Mol File:
218156-96-8.mol
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SRPK inhibitor Chemical Properties

Boiling point:
395.9±42.0 °C(Predicted)
Density 
1.306±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
pka
11.09±0.70(Predicted)
color 
white to beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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SRPK inhibitor Usage And Synthesis

Description

Serine/arginine-rich protein kinase 1 (SRPK1) targets proteins that contain multiple serine/arginine (SR) dipeptides, including SR-rich splicing factor 1, SRSF1. SRPIN340 is an isonicotinamide compound that inhibits SRPK1 (Ki = 0.89 μM). It is about 10-fold less effective against SRPK2 and does not inhibit the related SRPKs, Clk1 and Clk4. SRPIN340 suppresses the propagation of Sindbis virus in Vero cells and the replication of hepatitis C virus in Huh7/Rep-Feo-2a cells. By blocking SRPK1-mediated phosphorylation of SRSF1, SRPIN340 modulates alternative splicing of VEGF, reducing neovascularization both in cells and in animals.

Uses

SRPIN340 is a SRPK1 kinase inhibitor, which shows potential novel targeted therapeutic strategy in prostate cancer.

References

1) Fukuhara?et al.?(2006),?Utilization of host SR protein kinases and RNA-splicing machinery during viral replication; Proc. Natl. Acad. Sci. USA,?103?11329 2) Gammons?et al.?(2013),?SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurity; Invest. Ophthalmol. Vis. Sci.,?54?5797 3) Gammons?et al.?(2014),?Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma; Br. J. Cancer,?111?477

SRPK inhibitorSupplier

Shanghai Boyle Chemical Co., Ltd.
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Chembest Research Laboratories Limited
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+86-21-20908456
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China Langchem Inc.
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0086-21-58956006
Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
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Haoyuan Chemexpress Co., Ltd.
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021-58950125
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