Basic information Safety Supplier Related

SRI 31215

Basic information Safety Supplier Related

SRI 31215 Basic information

Product Name:
SRI 31215
Synonyms:
  • SRI 31215
  • SRI 31215 2TFA
  • SRI31215 2TFA
  • SRI-31215 2TFA
  • SRI31215 2TFA; SRI-31215 2TFA; SRI 31215 2TFA; SRI-31215 BIS-TFA SALT; SRI 31215 BIS-TFA SALT; SRI31215 BIS-TFA SALT
  • SRI-31215 Bis-TFA salt
  • SRI31215,c-Met/HGFR,SRI-31215,SRI 31215 TFA,inhibit,Inhibitor
  • SRI 31215 TFA, 10 mM in DMSO
CAS:
1832686-44-8
MF:
C27H34F3N5O3
MW:
533.6
Mol File:
1832686-44-8.mol
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SRI 31215 Chemical Properties

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
color 
Light yellow to khaki
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SRI 31215 Usage And Synthesis

Uses

SRI 31215 (TFA) is a Matriptase/Hepsin/hepatocyte growth factor activator (HGFA) triplex inhibitor and mimics the activity of HAI-1/2 (endogenous inhibitors of HGF activation). SRI 31215 has potent inhibitory activity against matriptase, hepsin and HGFA with IC50 values of 0.69 μM, 0.65 μM and 0.30 μM, respectively. SRI 31215 can be used for the research of cancer[1].

References

[1] Owusu BY, et al. Inhibition of pro-HGF activation by SRI31215, a novel approach to block oncogenic HGF/MET signaling. Oncotarget. 2016 May 17;7(20):29492-506. DOI:10.18632/oncotarget.8785

SRI 31215Supplier

Sichuan Wei Keqi Biological Technology Co., Ltd.
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028-81700200 18116577057
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3003855609@qq.com
Shanghai JiYi Biotechnology Co. Ltd.
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13621943973
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sales@shjiyipharmatech.com
Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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info@efebio.com
Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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3008007409@qq.com
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