HUMAN IL-21 Chemical Properties

storage temp. 

−20°C

form 

lyophilized powder

biological source

mouse

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

HUMAN IL-21 Usage And Synthesis

Epitope

aa2-224

Sensitivity

0.39 ng/mL

Immunogen

Synthetic peptide from C-Terminus of human CSNK1G2 (P78368, NP_001310). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset, Opossum (100%); Mouse, Rat, Elephant, Panda, Dog, Bovine, Pig, Platypus, Xenopus, Zebrafish (92%); Rabbit, Guinea pig, Salmon (85%); Orangutan, Bat, Horse (84%).

Detection

Colorimetric

Epitope

aa204-231

Reactivity

Duck

Immunogen

Recombinant human Dual oxidase 1 protein (1312-1551AA)

Epitope

aa109-138

Source_Species

E. coli

Conjugations

Biotin

Immunogen

Alpha-2-Macroglobulin.

Usage

The applications listed have been tested for the base form of this product. Alternate forms, such as conjugated, azide-free, or ready-to-use, have not been tested.

Tag

GST, N-terminus ; His, C-terminus

Epitope

C-Terminus

Reactivity

Pig

Reactivity

Mouse

Specificity

The antibody is a rabbit polyclonal antibody raised against FKBP3.

Epitope

aa56-83

Immunogen

Recombinant CSNK1d (Met1-Arg415)

Measurement

Format

Unconjugated, Unmodified

Format

Horseradish Peroxidase, Azide-free

Specificity

Human CSNK1G2

Format

FITC, Unmodified

Immunogen

DTW domain containing 2

Immunogen

Recombinant FKBP3 (Ala2-Asp224) expressed in E. coli.

Epitope

aa144-173

Specificity

Duck Alpha-2-Macroglobulin / A2M

Conjugations

Cy3

Epitope

aa35-84

Host

Rabbit

Format

Cy3, Unmodified

Format

Horseradish Peroxidase, Unmodified

Specificity

The antibody is a rabbit polyclonal antibody raised against CSNK1d.

Reactivity

Human; Chimpanzee; Gibbon; Monkey

Conjugations

HRP

Specificity

Human DTX1

Usage

Western Blot: Suggested dilution at 1 ug/ml in 5% skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as secondary antibody.

Detection_Range

0.78 - 50 ng/ml

Format

Allophycocyanin, Unmodified

Clonality

Polyclonal

Reactivity

Human; Mouse

Conjugations

FITC

Specificity

This DTWD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-173 amino acids from the Central region of human DTWD1.

Epitope

aa1-415

Reactivity

Mouse; Human

Conjugations

Unconjugated

Specificity

This DTX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-83 amino acids from the N-terminal region of human DTX4.

Specificity

This Mouse Csnk1d antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 204-231 amino acids from the Central region of mouse Csnk1d.

Specificity

This DTWD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from the Central region of human DTWD2.

Reactivity

Human

Conjugations

Allophycocyanin

Expression_System

E. coli

Format

Biotin, Unmodified

Immunogen

Synthetic peptide located between aa35-84 of human DTX1 (Q86Y01, NP_004407). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Galago, Marmoset, Mouse, Rat, Elephant, Panda, Dog, Bovine, Bat, Rabbit, Horse, Pig, Opossum (100%); Stickleback (85%).

Species

Human

Description

DTWD2 antibody is an unconjugated rabbit polyclonal antibody to human DTWD2. Validated for ELISA and IP.

Description

DTX4 antibody is an APC-conjugated rabbit polyclonal antibody to human DTX4 (aa56-83). Validated for ELISA and WB.

Description

DTWD1 antibody is an HRP-conjugated rabbit polyclonal antibody to human DTWD1 (aa144-173). Validated for ELISA and WB.

Description

CSNK1D antibody is an unconjugated rabbit polyclonal antibody to mouse CSNK1D (aa204-231). Validated for WB.

Description

CKI-Gamma 2 antibody is an FITC-conjugated rabbit polyclonal antibody to CKI-Gamma 2 (CSNK1G2) (C-Terminus) from human. It is reactive with human, chimpanzee, gibbon and other species. Validated for IHC and WB.

Description

DUOX antibody is an unconjugated rabbit polyclonal antibody to human DUOX. Validated for ELISA and IHC.

Description

DTX4 antibody is an unconjugated rabbit polyclonal antibody to human DTX4 (aa56-83). Validated for Flow, IHC and WB.

Description

FKBP3 antibody is a Cy3-conjugated rabbit polyclonal antibody to FKBP3 (FKBP25) (aa2-224) from mouse. It is reactive with human and mouse. Validated for WB.

Description

Deltex antibody is an unconjugated rabbit polyclonal antibody to human Deltex (DTX1) (aa35-84). Validated for WB.

Description

DTWD1 antibody is an APC-conjugated rabbit polyclonal antibody to human DTWD1 (aa144-173). Validated for ELISA and WB.

Description

DTWD2 antibody is an HRP-conjugated rabbit polyclonal antibody to DTWD2 (aa109-138) from human. It is reactive with human and mouse. Validated for ELISA and WB.

Description

Alpha-2-Macroglobulin antibody is a biotin-conjugated rabbit polyclonal antibody to duck Alpha-2-Macroglobulin (A2M). Validated for WB.

Description

DTWD1 antibody is a biotin-conjugated rabbit polyclonal antibody to human DTWD1 (aa144-173). Validated for ELISA and WB.

Description

FKBP3 antibody is an HRP-conjugated rabbit polyclonal antibody to FKBP3 (FKBP25) (aa2-224) from mouse. It is reactive with human and mouse. Validated for WB.

Description

CSNK1D antibody is an FITC-conjugated rabbit polyclonal antibody to human CSNK1D (aa1-415). Validated for WB.

Application

IHC; IHC-P; ELISA

Application

IHC; IHC-P; WB; FC

Application

WB; ELISA

Application

IP; ELISA

Application

IHC; IHC-P; WB

Application

WB

Biological Activity

IL-21 (interleukin-21) belongs to the IL-2 cytokine family. It is secreted by CD4+ T, natural killer (NK) and Th17 cells. IL-21 associates with IL-21 receptor and participates in B-cell proliferation, differentiation as well as apoptosis. It also promotes the cytotoxic activity of CD8+ T cells and natural killer cells.IL-21 plays a crucial role in the differentiation of follicular helper T cells. It also exhibits antitumor activity. It is also involved in the activation of JAK-ST at (Janus kinase - signal transducer and activator of transcription), PI3K (phosphatidylinositol 3-kinase) and MAPK (mitogen activated protein kinase) pathways.', 'IL-21 and its receptor have important roles in T and B cell proliferation and natural killer cell maturation. Human and mouse IL-21 share 57% amino acid identity.

target

CSNK1G2

target

CSNK1D

target

DTX4

target

Duck A2M

target

DTWD2

target

DTWD1

target

DTX1

target

DUOX

target

DUOX2

target

FKBP25

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