2-Chloro-4-methylaniline Chemical Properties

Melting point:

7 °C (lit.)

Boiling point:

223-225 °C (lit.)

Density 

1.151 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.575(lit.)

Flash point:

211 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

methanol: soluble

form 

Liquid

pka

3.09±0.10(Predicted)

color 

Clear yellow to pale brown

BRN 

774514

Stability:

Acid Sensitive, Light Sensitive

CAS DataBase Reference

615-65-6(CAS DataBase Reference)

NIST Chemistry Reference

Benzenamine, 2-chloro-4-methyl-(615-65-6)

EPA Substance Registry System

Benzenamine, 2-chloro-4-methyl- (615-65-6)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38-22-33

Safety Statements 

36/37-37/39-26-45-36/37/39

RIDADR 

UN 3429 6.1/PG 3

WGK Germany 

3

RTECS 

XU5110000

F 

8-9-23

Hazard Note 

Harmful

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29214200

Hazardous Substances Data

615-65-6(Hazardous Substances Data)

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Chloro-4-methylaniline Usage And Synthesis

Description

2-Chloro-4-methylaniline was used in determination of aniline derivatives in environmental water samples using on-line combination of supported liquid membrane extraction and liquid chromatography. It was also used in determination of amines in environmental water samples by gas chromatography–mass spectrometry. It is an intermediate used to prepare reverse transcriptase inhibitors of HIV-1.

Chemical Properties

clear yellow to pale brown liquid

Chemical Properties

The chloromethylanilines are colorless or white crystalline solids or liquids, some have a mild fishy odor.

Uses

2-Chloro-4-methylaniline is an intermediate used to prepare reverse transcriptase inhibitors of HIV-1.

Uses

2-Chloro-4-methylaniline was used in determination of aniline derivatives in environmental water samples using on-line combination of supported liquid membrane extraction and liquid chromatography. It was also used in determination of amines in environmental water samples by gas chromatography–mass spectrometry.

Safety Profile

Poison by ingestion. A severe eye and skin irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of Cland NOx. See also other chloro toluidine entries.

Potential Exposure

Most of the isomers are used in dyestuff manufacture. The 3-chloro-para isomer is used to kill birds. It is marketed as pelleted bait for control of bird populations.

Shipping

UN2239 Chlorotoluidines, solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3429 Chlorotoluidines, liquid, Hazard Class: 6.1; Labels: 6.1- Poisonous materials

Incompatibilities

Incompatible with oxidizers, strong acids; chloroformates, and acid anhydrides, isocyanates, aldehydes forming fire and explosive hazards.

2-Chloro-4-methylaniline(615-65-6)Related Product Information

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