Nomegestrol Chemical Properties

Boiling point:

502.6±50.0 °C(Predicted)

Density 

1.17±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Chloroform: soluble,DMSO: slightly soluble,Methanol: slightly soluble

form 

A solid

pka

12.99±0.60(Predicted)

Nomegestrol Usage And Synthesis

Description

Nomegestrol acetate is the 19-nor derivative of megestrol acetate, useful in the treatment of gynecological conditions associated with luteal deficiency.

Description

Nomegestrol is a derivative of 19-norprogesterone. It increases nuclear levels of the progesterone receptor in rat uterus when administered at a dose of 1 mg/animal.

Originator

Theramex (Monaco)

Uses

A progestogen, derivatives of which are used in contraceptives and hormone therapies.

Uses

Progetin used in implantable hormone replacement therapies.

Definition

ChEBI: Nomegestrol is a corticosteroid hormone.

brand name

LUTENYL

General Description

Nomegestrol acetate, 17-hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione acetate,is being investigated as the progestin component of anew oral contraceptive, in combination with the estrogenestradiol. This new combination, NOMAC/E2, is in phaseIII trials and would be the first oral contraceptive to utilizeestradiol itself as the estrogenic component. Structurally,NOMAC is considered a nor-progesterone derivative thatlacks the C19 methyl group in megestrol acetate.

Nomegestrol(58691-88-6)Related Product Information

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• Methyl acrylate
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• Kresoxim-methyl
• Methyl
• Dienogestrel
• Medroxyprogesterone Acetate
• Desogestrel
• Megestrol
• Ciclesonide
• Metandienone
• Testosterone enanthate
• Etonogestrel
• Vecuronium bromide
• Norethindrone
• Loteprednol etabonate