KGZHRAVDXGQUQM-WCQGTBRESA-N Usage And Synthesis

Uses

AZD5099, an antibacterial agent, is a potent and selective bacterial topoisomerase II inhibitor. AZD5099 potently inhibits the infections caused by Gram-positive and fastidious Gram-negative bacteria[1].

IC 50

Topoisomerase II

References

[1] Gregory S Basarab, et al. Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). J Med Chem. 2014 Jul 24;57(14):6060-82. DOI:10.1021/jm500462x

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