DEFEROXAMINE MESYLATE
DEFEROXAMINE MESYLATE Basic information
- Product Name:
- DEFEROXAMINE MESYLATE
- Synonyms:
-
- deferoxaminebmesylate
- deferoxaminemesilate
- deferoxaminemethanesulfonate
- desferal
- desferalmesylate
- desferalmethanesulfonate
- desferrioxaminebmesylate
- Deferoxamine Mesylate (300 mg)
- CAS:
- 138-14-7
- MF:
- C26H52N6O11S
- MW:
- 656.79
- EINECS:
- 205-314-3
- Product Categories:
-
- Inhibitors
- DESFERAL
- Aliphatics
- Amines
- Chelating Agents & Ligands
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Mol File:
- 138-14-7.mol
DEFEROXAMINE MESYLATE Chemical Properties
- Melting point:
- 148-149°
- storage temp.
- 2-8°C
- solubility
- H2O: 50 mg/mL
- form
- powder
- color
- white to off-white
- Water Solubility
- Soluble to 100 mM in water
Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 2
- RTECS
- UG5310000
- HS Code
- 29280000
- Toxicity
- man,TDLo,parenteral,16gm/kg/34W-I (16000mg/kg),CARDIAC: PERICARDITISGASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINEBLOOD: OTHER CHANGES,American Journal of Kidney Diseases. Vol. 10, Pg. 71, 1987.
MSDS
- Language:English Provider:SigmaAldrich
DEFEROXAMINE MESYLATE Usage And Synthesis
Description
Deferoxamine is a bacterial siderophore that chelates iron. It is used to experimentally inhibit iron-
Chemical Properties
DEFEROXAMINE MESYLATE is white or almost white powder.
Uses
chelating agent (Fe & Al)
Uses
DEFEROXAMINE MESYLATE is an iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients
brand name
Desferal (Novartis).
Biochem/physiol Actions
An iron chelator used often in the studies of cell proliferation and apoptosis. Has been shown to have anti-proliferative effects on vascular smooth muscle cells in vitro and in vivo and to arrest cells in the G1 phase. Also reported to induce p53. Induces apoptosis in HL-60 cells by chelating iron. After 48 hrs treatment with 1μM deferoxamine, DNA fragmentation was apparent. Cells treated with 0.1 μM deferoxamine for as little as 24 hours were committed to apoptosis; by 48 hrs nuclear collapse was observed. In some studies it has been shown to have antioxidant properties and to protect cells against H2O2-induced damage.
Clinical Use
Chelating agent:
Acute iron poisoning
Chronic iron or aluminium overload
Veterinary Drugs and Treatments
Deferoxamine is used for the treatment of either acute or chronic iron toxicity. It is being evaluated as an iron chelator for adjunctive treatment of acute cardiac ischemia and as a chelator for aluminum toxicity. Its efficacy in treating reperfusion injuries has been disappointing.
Drug interactions
Potentially hazardous interactions with other drugs
Avoid prochlorperazine, levomepromazine and
methotrimeprazine (prolonged unconsciousness).
Do not administer with blood.
Metabolism
When given parenterally desferrioxamine forms chelates with iron and aluminium ions to form ferrioxamine and aluminoxamine, respectively. The chelates are excreted in the urine and faeces via the bile. Desferrioxamine is metabolised, mainly in the plasma. Four metabolites of desferrioxamine were isolated from urine of patients with iron overload. The following biotransformation reactions were found to occur with desferrioxamine: transamination and oxidation yielding an acid metabolite, beta-oxidation also yielding an acid metabolite, decarboxylation and N-hydroxylation yielding neutral metabolites.
storage
Store at -20°C
DEFEROXAMINE MESYLATESupplier
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- 010-82848833 400-666-7788
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- 400-6009262 16621234537
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- 1-(800)-881-8210
- inquiries@lgmpharma.com
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- 021-50135380
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- Tel
- 0086-21-58956006
DEFEROXAMINE MESYLATE(138-14-7)Related Product Information
- Hydroxyurea
- Deferoxamine
- AMMONIUM FERRIC CHLORIDE
- Ammonium ferric sulfate dodecahydrate
- Ferric ammonium EDTA
- Ferrous ammonium sulfate hexahydrate
- AMMONIUM IRON (III) HEXACYANOFERRATE (II)
- Ferric ammonium citrate,brown
- Ammonium iron(III) sulfate
- Ferric ammonium oxalate
- MAFA
- Ammonium ferric citrate
- Ferric ammonium oxalate trihydrate
- DEFEROXAMINE MESYLATE
- NOCARDAMINE
- ferrimycin A1
- MAFA aqueous solution (5%)
- Deferoxamine Mesylate Salt