3-CHLORO-2-METHYLPYRIDINE Chemical Properties

Boiling point:

156.5±20.0 °C(Predicted)

Density 

1.150±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

pka

3.67±0.10(Predicted)

Appearance

Colorless to light yellow Liquid

Safety Information

HS Code 

2933399990

3-CHLORO-2-METHYLPYRIDINE Usage And Synthesis

Synthesis

General procedure for the synthesis of 3-chloro-2-methylpyridine from 3-amino-2-methylpyridine: 54 g of 3-amino-2-methylpyridine was slowly added to 130 g of concentrated hydrochloric acid (36-38% mass fraction). Subsequently, hydrogen chloride gas was passed to saturation and 222.45 g of phosphoryl chloride and 90 g of nitric acid at 70% mass concentration were added dropwise at 20-25°C. The reaction was carried out with continuous stirring and strict stirring. The reaction was carried out with continuous stirring and under strict temperature control. After completion of the reaction, 57.3 g of 3-chloro-2-methylpyridine was obtained in 89% yield and 99% purity after post-treatment.

References

[1] Patent: CN105061300, 2018, B. Location in patent: Paragraph 0020; 0021

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