N-ETHYLBENZISOXAZOLIUM TETRAFLUOROBORATE Chemical Properties

Melting point:

108-110 °C(lit.)

storage temp. 

Store at 0-5°C

solubility 

sol acetonitrile; slightly sol dichloromethane; sol aqueous acid (unstable above pH 4).

form 

crystalline solid

Sensitive 

Hygroscopic

CAS DataBase Reference

4611-62-5(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

22-24/25

WGK Germany 

3

F 

3-8-10-21

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

N-ETHYLBENZISOXAZOLIUM TETRAFLUOROBORATE Usage And Synthesis

Description

N-Ethylbenzisoxazolium Tetrafluoroborate is a peptide-coupling reagent; reacts with a wide range of nucleophiles to give o-hydroxy-N-ethylbenzamido derivatives.

Synthesis

N-Ethylbenzisoxazolium Tetrafluoroborate is prepared by ethylation of benzisoxazole with purified Triethyloxonium Tetrafluoroborate.

storage

The salt is reported not to be hygroscopic, although it etches glass on long exposure to moist air; should be protected from light; reported to be an irritant.

Purification Methods

Recrystallise it from MeCN/EtOAc to give magnificent crystals. It is not hygroscopic but on long exposure to moisture it etches glass. It is light-sensitive and should be stored in brown glass bottles. UV (H2O), max 258nm ( 13 100) and 297nm ( 2 900), IR (CH2Cl2):max 1613 (C=N) and 1111-1000 (BF 4 ) [UV, IR, NMR: Kemp & Woodward Tetrahedron 21 3019 1965].

N-ETHYLBENZISOXAZOLIUM TETRAFLUOROBORATE(4611-62-5)Related Product Information

• Fluoroboric acid
• Boron trifluoride dihydrate
• N-ETHYLBENZISOXAZOLIUM TETRAFLUOROBORATE
• 1,2-BENZISOXAZOLE
• Ammonium fluoborate
• Isoxazole
• Ethylamine-borontrifluoride