2-Hydroxyphenylacetic acid Chemical Properties

Melting point:

145-147 °C (lit.)

Boiling point:

240°C (estimate)

Density 

1.2143 (rough estimate)

refractive index 

1.4945 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Methanol, Water

form 

Crystalline Powder

pka

4.17±0.10(Predicted)

color 

Light pink to light brown

Water Solubility 

Soluble in Methanol and Water.

BRN 

908000

InChI

InChI=1S/C8H8O3/c9-7-4-2-1-3-6(7)5-8(10)11/h1-4,9H,5H2,(H,10,11)

InChIKey

CCVYRRGZDBSHFU-UHFFFAOYSA-N

SMILES

C1(CC(O)=O)=CC=CC=C1O

CAS DataBase Reference

614-75-5(CAS DataBase Reference)

NIST Chemistry Reference

Benzeneacetic acid, 2-hydroxy-(614-75-5)

EPA Substance Registry System

2-Hydroxyphenylacetic acid (614-75-5)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

10-23

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29182990

MSDS

• Language:English Provider:2-Hydroxyphenylacetic acid
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Hydroxyphenylacetic acid Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

2-Hydroxyphenylacetic Acid is an intermediate in the synthesis of atenolol and 3,4-dihydroxyphenylacetic acid.

Definition

ChEBI: A hydroxy monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 2-hydroxyphenyl group. It is a metabolite of phenylalanine and is excreted in the urine of patients suffering from diseases like phenylketonuria.

Purification Methods

Crystallise the acid from ether or chloroform (m 147o, m from latter solvent is always lower). [Beilstein 10 H 187, 10 I 81, 10 II 112, 10 III 422, 10 IV 536.]

2-Hydroxyphenylacetic acid(614-75-5)Related Product Information

• 3,4-Dihydroxyphenylacetic acid
• Salicylaldehyde
• Hyaluronic acid
• 3,5-Dihdyroxyphenylacetic acid
• Folic acid
• Citric acid
• 4-Methoxyphenylacetic acid
• 2'-Hydroxyacetophenone
• Ethyl 2-(Chlorosulfonyl)acetate
• Salicylic acid
• 2'-HYDROXYACETOPHENONE
• 2-HYDROXYPHENETHYL ALCOHOL
• 2-Cyanophenol
• Ascoric Acid
• M-HYDROXYPHENYLACETIC ACID,3-HYDROXYPHENYLACETIC ACID, 99+%
• Testosterone phenylacetate
• Phenylacetic acid
• Ethylenediamine-N,N'-bis((2-hydroxyphenyl)acetic acid)