5-Chloro-8-hydroxyquinoline Chemical Properties

Melting point:

122-124 °C(lit.)

Boiling point:

348.7±22.0 °C(Predicted)

Density 

1.2364 (rough estimate)

vapor pressure 

0.003Pa at 25℃

refractive index 

1.5330 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

0.019g/l (experimental)

form 

Powder

pka

3.77±0.10(Predicted)

color 

Light green to gray

Sensitive 

Light Sensitive

Merck 

14,2422

BRN 

5289

InChIKey

RWPWQYXFGFYJBA-UHFFFAOYSA-N

CAS DataBase Reference

130-16-5(CAS DataBase Reference)

NIST Chemistry Reference

8-Quinolinol, 5-chloro-(130-16-5)

EPA Substance Registry System

8-Quinolinol, 5-chloro- (130-16-5)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-24/25

WGK Germany 

3

RTECS 

VC4590000

TSCA 

Yes

HS Code 

29334990

MSDS

• Language:English Provider:Cloxiquine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

5-Chloro-8-hydroxyquinoline Usage And Synthesis

Chemical Properties

light green to grey powder

Uses

antibacterial, antifungal

Uses

Dermofungin, is an impurity of Cioquinol, which is an antifungal and antiprotozoal drug.

Definition

ChEBI: Cloxiquine is a member of quinolines and an organochlorine compound.

Synthesis Reference(s)

The Journal of Organic Chemistry, 70, p. 8590, 2005 DOI: 10.1021/jo051191x

in vitro

Cloxiquine (cloxyquin) exhibits antituberculosis activities, with MICs ranging from 0.062 to 0.25 μg/mL against 9 standard strains and 150 Mycobacterium tuberculosis .
Cloxiquine (0.5-10 μM; 24 h) suppresses both B16F10 and A375 cell growth in a dose-dependent manner.|
Cloxiquine (0.5-10 μM; 24 h) inhibits the migration of B16F10 and A375 cells.
Cloxiquine (0.5-2.5 μM; 24 h) suppresses glycolysis in B16F10 cells.

in vivo

Cloxiquine (5-25 mg/kg; i.p. daily for 8 d) suppresses tumor growth in a mouse B16F10 melanoma xenograft model.
Cloxiquine (5-25 mg/kg; i.p. daily for 14 d) suppresses tumor metastasis in mouse B16F10 melanoma lung metastatic model.

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