5-Chloro-8-hydroxyquinoline
5-Chloro-8-hydroxyquinoline Basic information
- Product Name:
- 5-Chloro-8-hydroxyquinoline
- Synonyms:
-
- 5-Chloro-8-quinolinol, >=98%
- 5-CHLORO-8-HYDROXYQUINOLINE
- 5-CHLORO-8-QUINOLINOL
- 5-CHLOROOXINE
- 5-CHLOROQUINOPHENOL
- Clioquinol EP Impurity A
- 5-Chloro-8-oxyquinoline
- 5-chloro-8-quinolino
- CAS:
- 130-16-5
- MF:
- C9H6ClNO
- MW:
- 179.6
- EINECS:
- 204-978-1
- Product Categories:
-
- Quinolines
- Haloquinolines
- Quinolines, Quinazolines and derivatives
- Hydroxyquinolines
- pesticide intermediates
- API
- 130-16-5
- Mol File:
- 130-16-5.mol
5-Chloro-8-hydroxyquinoline Chemical Properties
- Melting point:
- 122-124 °C(lit.)
- Boiling point:
- 348.7±22.0 °C(Predicted)
- Density
- 1.2364 (rough estimate)
- vapor pressure
- 0.003Pa at 25℃
- refractive index
- 1.5330 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- 0.019g/l (experimental)
- form
- Powder
- pka
- 3.77±0.10(Predicted)
- color
- Light green to gray
- Sensitive
- Light Sensitive
- Merck
- 14,2422
- BRN
- 5289
- InChIKey
- RWPWQYXFGFYJBA-UHFFFAOYSA-N
- CAS DataBase Reference
- 130-16-5(CAS DataBase Reference)
- NIST Chemistry Reference
- 8-Quinolinol, 5-chloro-(130-16-5)
- EPA Substance Registry System
- 8-Quinolinol, 5-chloro- (130-16-5)
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-24/25
- WGK Germany
- 3
- RTECS
- VC4590000
- TSCA
- Yes
- HS Code
- 29334990
MSDS
- Language:English Provider:Cloxiquine
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
5-Chloro-8-hydroxyquinoline Usage And Synthesis
Chemical Properties
light green to grey powder
Uses
antibacterial, antifungal
Uses
Dermofungin, is an impurity of Cioquinol, which is an antifungal and antiprotozoal drug.
Definition
ChEBI: Cloxiquine is a member of quinolines and an organochlorine compound.
Synthesis Reference(s)
The Journal of Organic Chemistry, 70, p. 8590, 2005 DOI: 10.1021/jo051191x
in vitro
Cloxiquine (cloxyquin) exhibits antituberculosis activities, with MICs ranging from 0.062 to 0.25 μg/mL against 9 standard strains and 150 Mycobacterium tuberculosis .
Cloxiquine (0.5-10 μM; 24 h) suppresses both B16F10 and A375 cell growth in a dose-dependent manner.|
Cloxiquine (0.5-10 μM; 24 h) inhibits the migration of B16F10 and A375 cells.
Cloxiquine (0.5-2.5 μM; 24 h) suppresses glycolysis in B16F10 cells.
in vivo
Cloxiquine (5-25 mg/kg; i.p. daily for 8 d) suppresses tumor growth in a mouse B16F10 melanoma xenograft model.
Cloxiquine (5-25 mg/kg; i.p. daily for 14 d) suppresses tumor metastasis in mouse B16F10 melanoma lung metastatic model.
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5-Chloro-8-hydroxyquinoline(130-16-5)Related Product Information
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- Quinhydrone
- 5,7-Dichloro-8-hydroxyquinoline
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- 5,8-DICHLORO-4-HYDROXYQUINOLINE
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- 7-CHLORO-2-HYDROXYQUINOLINE,7-CHLORO-2-HYDROXYQUINOLINE, 98+%
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