5,7-Dichloro-8-hydroxyquinaldine Chemical Properties

Melting point:

108-112 °C (dec.)(lit.)

Boiling point:

350.7±37.0 °C(Predicted)

Density 

1.3126 (rough estimate)

refractive index 

1.5500 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

DMSO, Methaol (Slightly)

form 

Solid

pka

2.47±0.30(Predicted)

color 

Dark Beige to Very Dark Beige

Water Solubility 

Insoluble

Merck 

13,2209

BRN 

156683

CAS DataBase Reference

72-80-0(CAS DataBase Reference)

NIST Chemistry Reference

Chlorquinaldol(72-80-0)

Safety Information

Hazard Codes 

Xn,T

Risk Statements 

22-36/37/38-23/24/25

Safety Statements 

26-36-36/37/39-45

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

VC5600000

HS Code 

2933998090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

5,7-Dichloro-8-hydroxyquinaldine Usage And Synthesis

Chemical Properties

yellowish to beige-brown powder

Originator

Sterosan ,Geigy ,US ,1954

Uses

Chlorquinaldol is a fungistat and antibacterial agent in topical pharmaceutical preparations (5,7-dichloro-2-methyl-8-quinolinol, Sterosan).

Uses

antiinfectant, antifungal

Uses

5,7-Dichloro-8-hydroxy-2-methylquinoline is an anti-infective agent.

Definition

ChEBI: A monohydroxyquinoline that is quinolin-8-ol which is substituted by a methyl group at position 2 and by chlorine at positions 5 and 7. An antifungal and antibacterial, it was formerly used for topical treatment of skin conditions and vaginal infections.

Manufacturing Process

11.1 parts of 8-hydroxy-quinaldine are dissolved in 140 parts of formic acid. Chlorine is introduced into this solution under cooling, until the increase in weight corresponds to the required quantity of chlorine and a test of the chlorination mixtures gives no more dyestuff formation with diazo-benzene in an acetic acid solution
When the chlorination is complete, the reaction mixture is poured into 1,000 parts of water and treated with a dilute sodium bisulfite solution, until no more reaction may be observed with starch potassium iodide paper. Thereby the 5,7-dichloro-8-hydroxy-quinaldine separates out in form of a weakly yellowish colored precipitate. The same is filtered off and thoroughly washed with water.After drying, 15 parts of 5,7-dichloro-8-hydroxy-quinaldine melting at 111°C to 112°C are obtained. When recrystallized from alcohol, the product is obtained in voluminous, slightly yellowish needles having the melting point of 111.5°C to 112°C.

Therapeutic Function

Antibacterial

Purification Methods

Crystallise it from EtOH. [Beilstein 21/3 V 346.]

5,7-Dichloro-8-hydroxyquinaldine(72-80-0)Related Product Information

• PIERICIDIN A
• Clotrimazole
• Antimicrobial
• 5-CHLOROQUINOLINE
• Halquinol
• 2,4-Dichlorophenol
• 5-Chloro-8-hydroxyquinoline
• 5,7-Dichloro-8-hydroxyquinaldine
• 8-Hydroxyquinaldine
• 5,7-Dichloro-8-hydroxyquinoline
• 7-Chloro-2-methylquinoline
• 7-CHLOROQUINOLINE
• 5-Chloroquinaldine
• 5,7-DICHLORO-2-METHYLQUINOLINE
• 8-HYDROXYQUINOLINE HYDROCHLORIDE
• 3-[(5,7-dichloro-2-methylquinolin-8-yl)oxy]propanoic acid
• (5,7-DICHLORO-2-METHYL-QUINOLIN-8-YLOXY)-ACETIC ACID HYDRAZIDE
• (5,7-DICHLORO-2-METHYL-QUINOLIN-8-YLOXY)-ACETIC ACID