SKULLCAPFLAVONE I Chemical Properties

Melting point:

254-256℃

Boiling point:

573.6±50.0 °C(Predicted)

Density 

1.402

solubility 

Soluble in chloroform and methanol;

form 

powder

pka

6.81±0.40(Predicted)

color 

Yellow

Water Solubility 

insoluble in water

InChI

1S/C17H14O6/c1-21-14-8-12(20)15-11(19)7-13(23-17(15)16(14)22-2)9-5-3-4-6-10(9)18/h3-8,18,20H,1-2H3

InChIKey

CZRGNFVQUYWGKP-UHFFFAOYSA-N

SMILES

OC1=C(C(C=C(C2=CC=CC=C2O)O3)=O)C3=C(OC)C(OC)=C1

Safety Information

WGK Germany 

WGK 3

Storage Class

13 - Non Combustible Solids

SKULLCAPFLAVONE I Usage And Synthesis

Uses

Skullcapflavone I can be isolated from A. nallamalayana. Skullcapflavone I inhibits collagenase and elastase enzyme with IC50s of 106.74 μM and 186.70 μM. Skullcapflavone I has anticancer activities by down-regulating miR-23a[1].

target

Caspase | NO | PGE | IL Receptor

References

[1] Yang B, et al. Anti-cancer, Anti-collagenase and Anti-elastase Potentials of Some Natural Derivatives: In vitro and in silico Studies. J Oleo Sci. 2023;72(5):557-570. DOI:10.5650/jos.ess22337
[2] Cui J, et al. Skullcapflavone I has a potent anti-pancreatic cancer activity by targeting miR-23a. Biofactors. 2020 Sep;46(5):821-830. DOI:10.1002/biof.1621

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