Methyl 4-(chloroformyl)butyrate Chemical Properties

Boiling point:

110 °C/17 mmHg (lit.)

Density 

1.191 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.445(lit.)

Flash point:

180 °F

storage temp. 

Inert atmosphere,2-8°C

solubility 

Chloroform, Hexane

form 

Oil

color 

Clear Colourless

Water Solubility 

reacts

Sensitive 

Moisture Sensitive

BRN 

1762383

CAS DataBase Reference

1501-26-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45-24/25

RIDADR 

UN 3265 8/PG 2

WGK Germany 

3

F 

10-21

HazardClass 

8

PackingGroup 

II

HS Code 

2918300090

MSDS

• Language:English Provider:Methyl glutaryl chloride
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Methyl 4-(chloroformyl)butyrate Usage And Synthesis

Chemical Properties

clear colourless to light yellow liquid

Uses

Methyl 4-(Chloroformyl)butyrate is used in the synthesis of Leukotriene B4, a proinflammatory agent produced from leukocytes.

Synthesis

1. 100 g (0.878 mol) of glutaric anhydride was dissolved in 50 mL of anhydrous methanol and heated to reflux for 1 h. 2. Upon completion of the reaction, unreacted methanol was removed by distillation under reduced pressure. 3. The reaction mixture was cooled to room temperature, and 200 mL of acetochloride was slowly added. 4. The reaction mixture was heated for 6 h., wherein after 2 h of heating the remaining dichloro sulfoxide.5. Finally, the fractions were dried at 96 °C to 98 °C/10 mmHg to give 124.2 g of methyl 4-chlorocarbonylbutyrate as a light yellow liquid in 86.4% yield.

References

[1] Patent: CN103864658, 2016, B. Location in patent: Paragraph 0056; 0057
[2] Tetrahedron Letters, 1984, vol. 25, # 39, p. 4371 - 4374
[3] Journal of Enzyme Inhibition and Medicinal Chemistry, 2016, vol. 31, # 6, p. 915 - 923

Methyl 4-(chloroformyl)butyrate(1501-26-4)Related Product Information

• Pirimiphos-methyl
• METSULFURON METHYL
• Methyl butyrate
• Tribenuron methyl
• Kresoxim-methyl
• Ethyl malonyl chloride
• Indole-3-butyric acid
• 4-Aminobutyric acid
• Methyl 4-chlorobutyrate
• Butyric Acid
• Hydrocortisone-17-butyrate
• Methyl salicylate
• Methyl acetate
• Thiophanate-methyl
• Methyl
• Methyl bromide
• Parathion-methyl
• METHYL VALERATE