4-Bromo-5-fluoro-2-nitrotoluene Chemical Properties

Melting point:

59-63°C

Boiling point:

266.6±35.0 °C(Predicted)

Density 

1.696±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

solid

color 

Cream

InChIKey

MTTNTJRJOFVWSY-UHFFFAOYSA-N

CAS DataBase Reference

224185-19-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36-36/37/38

Safety Statements 

26-36/37-36

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29049090

MSDS

• Language:English Provider:SigmaAldrich

4-Bromo-5-fluoro-2-nitrotoluene Usage And Synthesis

Chemical Properties

pale yellow powder

Synthesis

2-Fluoro-4-methyl-5-nitro-aniline (1.85 g, 10.90 mmol) was suspended in concentrated hydrobromic acid (22 ml_) and cooled to 0 ℃. Solution of sodium nitrite (0.83 g, 12.00 mmol) in water (3.6 ml_) was added dropwise while maintaining the temperature at 0-5 °C. After stirring for 15 min, the mixture was filtered through a cotton pad and slowly poured into a solution of cuprous oxide (2.60 g, 17.5 mmol) and concentrated hydrobromic acid (20 ml) at 0 °C. After stirring overnight, the reaction mixture was diluted with EtOAc, washed with 10 % aq NaOH and 5percent aq Na2S2Os successively, dried over MgSO4, filtered and concentrated. The residue was purified by column chromatography (ethyl acetate: hexane; 2:98) to afford 1-Bromo-2-fluoro-4- methyl-5-nitro-benzene as a colorless oil (2.30 g, 91 %).

References

[1] Patent: WO2003/99824, 2003, A1. Location in patent: Page 32
[2] Patent: WO2003/99275, 2003, A1. Location in patent: Page 65
[3] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 2, p. 457 - 460
[4] Patent: WO2015/54572, 2015, A1. Location in patent: Page/Page column 247
[5] Patent: US2004/224973, 2004, A1. Location in patent: Page 21

4-Bromo-5-fluoro-2-nitrotoluene(224185-19-7)Related Product Information

• 4-Nitrotoluene
• 2-Nitro-4-methylsulfonyltoluene
• 2-Nitrotoluene
• 3-Nitrotoluene
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• 4-Bromo-2-nitrotoluene
• DINITROTOLUENE
• Fluorine
• Bromine
• 2,4,6-Trinitrotoluene
• 3-Bromo-4-fluoronitrobenzene
• 5-Fluoro-2-nitrotoluene
• 3-Bromo-4-fluoroaniline
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• 5-BROMO-4-FLUORO-2-METHYLANILINE
• 4-BROMO-5-FLUORO-2-NITROBENZOIC ACID
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• 5-Bromo-2-fluoro-4-nitrotoluene,5-Bromo-2-fluoro-4-nitrotoluene