GSK2894631A Chemical Properties

Boiling point:

572.5±45.0 °C(Predicted)

Density 

1.27±0.1 g/cm3(Predicted)

storage temp. 

4°C, away from moisture and light

solubility 

DMSO:150.0(Max Conc. mg/mL);396.39(Max Conc. mM)

form 

Solid

pka

13.22±0.40(Predicted)

color 

White to off-white

GSK2894631A Usage And Synthesis

Uses

HPGDS inhibitor 2 is a highly potent and selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with an IC50 of 9.9 nM[1].

References

[1] Deaton DN, et al. The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors. Bioorg Med Chem. 2019 Apr 15;27(8):1456-1478. DOI:10.1016/j.bmc.2019.02.017

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