ETHYLHYDROCUPREINE
ETHYLHYDROCUPREINE Basic information
- Product Name:
- ETHYLHYDROCUPREINE
- Synonyms:
-
- optochin
- optoquine
- ethylhydrocupreine free base*crystalline
- Numoquine
- Optochine
- Ethylhydrocuprein
- Hydrocupureine ethyl ether
- Cinchonan-9-ol,6'-ethoxy-10,11-dihydro-, (8a,9R)-
- CAS:
- 522-60-1
- MF:
- C21H28N2O2
- MW:
- 340.46
- EINECS:
- 208-333-5
- Product Categories:
-
- Miscellaneous
- Mol File:
- 522-60-1.mol
ETHYLHYDROCUPREINE Chemical Properties
- Melting point:
- 123-128° when solvent-free
- alpha
- D25 -136.2° (alcohol)
- Boiling point:
- 476.25°C (rough estimate)
- Density
- 1.1027 (rough estimate)
- refractive index
- 1.6180 (estimate)
- storage temp.
- 2-8°C
MSDS
- Language:English Provider:SigmaAldrich
ETHYLHYDROCUPREINE Usage And Synthesis
Uses
Ethylhydrocupreine is an antibiotic tested against isolates of Streptococcus mitis resulting in an 100% resistance. Also, ethylhydrocupreine susceptibility test is a key method for differentiating Streptococcus pneumoniae from other α-hemolytic streptococci.
Definition
ChEBI: A cinchona alkaloid consisting of 10,11-dihydrocinchonan bearing hydroxy and ethoxy substituents at positions 9 and 6' respectively.
in vivo
The injection of 1 cc. of a 24 hour dextrose blood broth culture of virulent Type I pneumococci into the right pleural cavity of guinea pigs produces acute suppurative pleuritis on both sides associated with suppurative pericarditis. The injection of 1 cc. of 1:500 solutions of Ethylhydrocupreine hydrochloride into each pleural cavity of guinea pigs at varying intervals up to 24 hours after pleural infection has usually shown a marked curative influence. Similar results are observed with dogs[1].
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