LY 303511 Chemical Properties

Boiling point:

496.1±45.0 °C(Predicted)

Density 

1.237±0.06 g/cm3(Predicted)

storage temp. 

Store at +4°C

solubility 

Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO

form 

Amber solid

pka

9.20±0.10(Predicted)

LY 303511 Usage And Synthesis

Uses

LY 303511 is an inactive analog of the phosphoinositide 3-kinase inhibitor LY294002.

Definition

ChEBI: 8-phenyl-2-(1-piperazinyl)-1-benzopyran-4-one is a N-arylpiperazine.

Biological Activity

Negative control compound with respect to LY 294004 (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-onehydrochloride ) PI 3-kinase inhibitory activity. Blocks voltage-gated potassium (K v ) channels (IC 50 = 64.6 μ M) and inhibits IL-1 β -stimulated NF- κ B activation, attenuating MCP-1 expression. Anti-proliferative.

LY 303511(154447-38-8)Related Product Information

• Isopropylamine
• 2,5-Dimethoxyaniline
• tert-Butyl 1-piperazinecarboxylate
• 2-(Etilmetilammino)-8-fenilcromone [Italian]
• 2-(Diethylamino)-8-phenyl-4H-1-benzopyran-4-one
• TRANS-3-(DIETHYLAMINO)-1-(2-HYDROXY-
• LY 303511
• 4H-1-Benzopyran-4-one, 2-(diethylamino)-
• 2-(Dimethylamino)-8-phenyl-4H-1-benzopyran-4-one