Sobuzoxane
Sobuzoxane Basic information
- Product Name:
- Sobuzoxane
- Synonyms:
-
- 1,2-bis(4-isobutoxycarbonyloxymethyl-3,5-dioxo-piperazin-1-yl)ethane
- 1,2-ethanediylbis((2,6-dioxo-4,1-piperazinediyl)methylene)bis(2-carbonicaci
- 4,4’-ethylenebis(1-(hydroxymethyl)-2,6-piperazinedione)bis(isobutylcarbonat
- e)(ester)
- methylpropyl)ester
- MST-16, 4,4μ-(1,2-Ethanediyl)bis(1-isobutoxycarbonyloxmethyl-2,6-piperazinedione)
- 4,4'-Ethylenebis(2,6-dioxopiperazine-1-methanol)bis(2-methylpropoxyformate)
- Perazoline
- CAS:
- 98631-95-9
- MF:
- C22H34N4O10
- MW:
- 514.53
- Mol File:
- 98631-95-9.mol
Sobuzoxane Chemical Properties
- Melting point:
- 128-130°; mp 132-133° (Cai, 1989)
- Boiling point:
- 664.9±55.0 °C(Predicted)
- Density
- 1.272±0.06 g/cm3(Predicted)
- solubility
- DMSO: 19 mg/mL
- form
- solid
- pka
- 2.75±0.20(Predicted)
Sobuzoxane Usage And Synthesis
Description
Sobuzoxane, a novel bis(2,6-dioxopiperazine) derivative, was introduced in Japan for the treatment of malignant lymphoma and adult T-cell IeukemiaQmphoma (ATLL), which is resistant to chemotherapy and has a poor prognosis. Sobuzoxane exhibits 8 broad spectrum of antitumor activity. It is a noncleavable complexstabilizing topoisomerase II inhibitor and exerts its function via interfering with the catalytic activity of the enzyme to result in an irreversible inhibition of cell division by blockade of chromosome condensation and segregation. Due to Its unique mode of cytocidai activity, it has no cross resistance with many currently available anticancer agents. Sobuzoxane is reported to significantly inhibit growth of human colon, lung, gastric, and breast cancers and is in clinical trials for these indications.
Originator
Zenyaku Kogyo (Japan)
Uses
Sobuzoxane is an inhibitor of DNA topoisomerase II which induces apoptosis.
Definition
ChEBI: Sobuzoxane is an organic molecular entity.
brand name
Perazolln
SobuzoxaneSupplier
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- 1-(800)-881-8210
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- 027-88041443 13072715837
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- +8618523575427
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- +1-833-552-7181
- sales@aladdinsci.com
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Sobuzoxane(98631-95-9)Related Product Information
- 1,4-Dioxane
- Isobutylene oxide
- Propylene oxide
- ETHANE
- 1,1,1-Tris(hydroxymethyl)ethane
- 1-Methylpiperazine
- ETHYLIMINUM
- 4-(2-AMINO-ETHYL)-PIPERAZIN-2-ONE
- AMMONIUM CARBONATE
- TRIETHYLAMMONIUM FORMATE
- Piperazine-2,6-dione
- 1,1,4,7,10,10-HEXAMETHYLTRIETHYLENETETRAMINE
- 4-methylpiperazine-2,6-dione
- 1,1'-ethylenedipiperazine
- Sobuzoxane