Basic information Safety Supplier Related

POLY-L-HISTIDINE HYDROCHLORIDE MW

Basic information Safety Supplier Related

POLY-L-HISTIDINE HYDROCHLORIDE MW Basic information

Product Name:
POLY-L-HISTIDINE HYDROCHLORIDE MW
Synonyms:
  • polyhistidine
  • POLY-L-HISTIDINE HYDROCHLORIDE MW
  • POLY-L-HISTIDINE MOL WT 5000-15000
  • POLY-L-HISTIDINE, HYDROCHLORIDE*MW 15,00 0-50,000
  • poly-L-HistidineMW5000-15000
  • poly-L-histidine chloride
  • Poly-L-histidine mol wt 5,000-25,000
CAS:
26062-48-6
MF:
C6H9N3O2
MW:
155.16
Product Categories:
  • Amino Acids
  • Homopolymers
  • Polyamino Acids
Mol File:
26062-48-6.mol
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POLY-L-HISTIDINE HYDROCHLORIDE MW Chemical Properties

storage temp. 
-20°C
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Safety Information

WGK Germany 
3
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POLY-L-HISTIDINE HYDROCHLORIDE MW Usage And Synthesis

Uses

Poly-L-histidine has been used:

  • as a polycation for the dispersion of multi-wall carbon nanotubes (MWCNTs)
  • as a polyionic compound to investigate its ability to rupture extracellular enveloped virus membrane
  • in screening its anti-prion activity in cell based and in vivo anti-prion assay

Definition

ChEBI: Histidine is an alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3. It has a role as a metabolite. It is an alpha-amino acid, a member of imidazoles, an aromatic amino acid and a polar amino acid. It contains a 1H-imidazol-4-ylmethyl group. It is a conjugate base of a histidinium(1+). It is a conjugate acid of a histidinate(1-).

General Description

Poly-L-histidine is an amphoteric compound. The imidazole ring in its structure enables protonation?deprotonation.

Biochem/physiol Actions

Poly-L-histidine (Phis) copolymers are biocompatible, pH responsive and are less toxic. It exhibits endolysosomal escape funcationality. The copolymer of Phis with poly(ethylene glycol)?poly(d,l-lactide) (PEG-PLA) is effective in delivering doxorubicin. pH sensitive poly(l-histidine) copolymer micelles have application in delivering anticancer drugs in acidic microenvironment.

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