L-Histidine hydrochloride Chemical Properties

Melting point:

240-245 °C (dec.)

alpha 

[α]D20 +7.0～+10.0°(c=2,HCl)

storage temp. 

Inert atmosphere,Room Temperature

Appearance

White to off-white Solid

InChI

InChI=1/C6H9N3O2.ClH/c7-5(6(10)11)1-4-2-8-3-9-4;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H/t5-;/s3

InChIKey

QZNNVYOVQUKYSC-USHJBNIQNA-N

SMILES

C(C1N=CNC=1)[C@H](N)C(=O)O.Cl |&1:6,r|

CAS DataBase Reference

1007-42-7(CAS DataBase Reference)

Safety Information

Safety Statements 

22-24/25

RIDADR 

UN 1789 8/PG 3

WGK Germany 

3

F 

3-10

MSDS

• Language:English Provider:SigmaAldrich

L-Histidine hydrochloride Usage And Synthesis

Uses

Amino acid drugs, the main component of amino acid infusions and comprehensive amino acid preparations; used as an adjunct treatment for peptic ulcers. Also used for cardiovascular diseases such as anemia, aortitis, and heart failure; a nutritional supplement, as the body synthesizes amino acids slowly, making them quasi-essential amino acids, which can be used to fortify infant formula and post-surgical patient food.

Purification Methods

The dihydrochloride crystallises from water or aqueous EtOH and is washed with acetone, then diethyl ether. Alternatively convert it to the histidine di-(3,4-dichlorobenzenesulfonate) salt by dissolving 3,4-dichlorobenzenesulfonic acid (1.5g/10mL) in the aqueous histidine solution with warming, and then the solution is cooled in ice. The resulting crystals (m 280o dec) can be recrystallised from 5% aqueous 3,4-dichlorobenzenesulfonic acid, then dried over CaCl2 under vacuum, and washed with diethyl ether to remove Purification of Biochemicals — Amino Acids and Peptides excess reagent. The dihydrochloride can be regenerated by passing the solution through a Dowex-1 (Cl-form) ion-exchange column. The solid is obtained by evaporation of the solution on a steam bath or better in a vacuum. [Greenstein & Winitz, The Amino Acids Vol 3 p 1976 1961, Beilstein 25/16 V 366.]

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