trans-2-Benzylamino-1-cyclohexanol Chemical Properties

Melting point:

69-72 °C

Boiling point:

69-72°C

Density 

0.9923 (rough estimate)

refractive index 

1.5175 (estimate)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

crystal

pka

14.83±0.40(Predicted)

color 

white

Safety Information

Risk Statements 

11-36/37/38

Safety Statements 

24/25

TSCA 

No

HS Code 

2921490090

MSDS

• Language:English Provider:ACROS
• Language:English Provider:ALFA

trans-2-Benzylamino-1-cyclohexanol Usage And Synthesis

Chemical Properties

VERY SLIGHTLY YELLOW TO BEIGE CRYSTALLINE POWDER

Uses

suzuki reaction

Synthesis

General procedure for the synthesis of trans-2-benzylaminocyclohexanol from cyclohexene oxide and benzylamine: cyclohexene oxide (20 g, 204 mmol) was mixed with benzylamine (44 g, 411 mmol), and the reaction was carried out for 6 hours at 80 °C. After completion of the reaction, the excess benzylamine was removed by distillation under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent being a chloroform solution of 5-10% methanol to give (1RS,2RS)-trans-2-benzylaminocyclohexanol (26 g, 127 mmol, 62% yield) as white crystals.

References

[1] Tetrahedron Letters, 2008, vol. 49, # 9, p. 1546 - 1550
[2] Tetrahedron, 2011, vol. 67, # 47, p. 9214 - 9218
[3] Journal of Organic Chemistry, 2007, vol. 72, # 10, p. 3713 - 3722
[4] Tetrahedron Letters, 1990, vol. 31, # 32, p. 4661 - 4664
[5] Synthetic Communications, 2001, vol. 31, # 21, p. 3295 - 3302

trans-2-Benzylamino-1-cyclohexanol(40571-86-6)Related Product Information

• trans,trans-2,4-Undecadienal
• 2-Aminocyclohexanol
• trans-4-Aminocyclohexanol
• Cyclohexanol
• 1-Methylcyclohexanol
• 4-Aminocyclohexanol
• Cyclamic acid
• Molasses
• Ethylene glycol
• TRANS-2-(4-METHOXY-BENZYLAMINO)-CYCLOHEXANOL
• trans-2-Benzylamino-1-cyclohexanol