3-METHYLGLUTACONIC ACID
3-METHYLGLUTACONIC ACID Basic information
- Product Name:
- 3-METHYLGLUTACONIC ACID
- Synonyms:
-
- 3-METHYL-PENT-2-ENEDIOIC ACID
- 3-METHYLGLUTACONIC ACID
- 3-METHYL-2-PENTENEDIOIC ACID
- 3-Methyl-delta^2-penten-1,5-dioic acid
- glutacouic acide 3-methyl
- 3-Methylglutaconic acid, mixture of E and Z isomers
- NSC 249232
- (E)-3-methylglutaconic acid
- CAS:
- 5746-90-7
- MF:
- C6H8O4
- MW:
- 144.13
- Mol File:
- 5746-90-7.mol
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3-METHYLGLUTACONIC ACID Chemical Properties
- Melting point:
- 115 °C
- Boiling point:
- 399.4±25.0 °C(Predicted)
- Density
- 1.307±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.36±0.10(Predicted)
- color
- White to Light Beige
- BRN
- 1722907
- Stability:
- Hygroscopic
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3-METHYLGLUTACONIC ACID Usage And Synthesis
Uses
3-Methylglutaconic acid is a glutarate which builds up in the urine in 3-methylglutaconic aciduria. 3-methylglutaconic aciduria is a term used to describe five different disorders that impair the functioning of energy-producing centers within cells (mitochondria)
Definition
ChEBI: A dicarboxylic acid comprising (E)-glutaconic acid carrying a 3-methyl substituent.
Biological Activity
3-Methylglutaconic acid is a metabolite (as the CoA thioester) in the leucine degradative pathway as well as the mevalonate shunt, a pathway th at links isoprenoid metabolism with mitochondrial acetyl-CoA metabolism. 3-Methylglutaconic acid accumulates in patients with a deficiency of 3-methylglutaconyl-CoA hydratase.
in vivo
| Animal Model: | Male Sprague-Dawley rats and male Hartley guinea-pigs[2] |
| Dosage: | 0.16 mL/kg, 90 min |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Increased initial blood pressure and heart rate in rats followed by vagal bradycardia and hypotension (rat) Developed three patterns of cardiovascular changes (Type 1: a period of sympathetically-mediated hypertension and tachycardia followed by vagal bradycardia; Type 2: Increased arterial pressure and heart rate, but no vagal activation; Type 3: exhibited no significant cardiovascular changes(Guinea-pigs). |
| Animal Model: | Male Wistar rats[3] |
| Dosage: | 45mg/kg for single dose, 4days |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Decreased in NR2B expression on the whole cerebellum tissue and Purkinje cells. |
3-METHYLGLUTACONIC ACIDSupplier
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