4-Ethylbenzaldehyde Chemical Properties

Boiling point:

221 °C (lit.)

Density 

0.979 g/mL at 25 °C (lit.)

vapor pressure 

16.67Pa at 25℃

refractive index 

n20/D 1.539(lit.)

FEMA 

3756 | 4-ETHYLBENZALDEHYDE

Flash point:

198 °F

storage temp. 

4°C, stored under nitroge

form 

Liquid

color 

Clear colorless to light yellow

Odor

at 10.00 % in dipropylene glycol. bitter almond sweet anise

Odor Type

fruity

biological source

synthetic

Water Solubility 

Not miscible or difficult to mix in water. Soluble in alcohol.

Sensitive 

Air Sensitive

JECFA Number

865

BRN 

636027

InChIKey

QNGNSVIICDLXHT-UHFFFAOYSA-N

LogP

2.75 at 25℃

CAS DataBase Reference

4748-78-1(CAS DataBase Reference)

NIST Chemistry Reference

Benzaldehyde, 4-ethyl-(4748-78-1)

EPA Substance Registry System

Benzaldehyde, 4-ethyl- (4748-78-1)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-27-28-36/37/39-37/39

WGK Germany 

3

TSCA 

Yes

HazardClass 

IRRITANT

HS Code 

29122990

MSDS

• Language:English Provider:4-Ethylbenzaldehyde
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4-Ethylbenzaldehyde Usage And Synthesis

Chemical Properties

CLEAR COLOURLESS TO SLIGHTLY YELLOW LIQUID

Chemical Properties

4-Ethylbenzaldehyde has a sweet, bitter-almond odor

Occurrence

Reported found in roasted turkey, grilled and roasted beef, roasted chicken, cider, black tea, roasted peanuts and cooked trassi

Uses

It is used as a perfuming agent in cosmetics industry. It is also used as a pharmaceutical intermediate.

Uses

4-Ethylbenzaldehyde has been used in the synthesis of 4,4′-diaminotriphenylmethanes under microwave irradiation, which is useful for parallel library syntheses.

Definition

ChEBI: 4-Ethylbenzaldehyde is a carbonyl compound.

Aroma threshold values

Detection: 13 ppb; recognition: 40 ppb

Synthesis Reference(s)

Synthetic Communications, 26, p. 315, 1996 DOI: 10.1080/00397919608003620

General Description

4-Ethylbenzaldehyde is a by-product of disinfection. Kinetic constants (KI) of 4-ethylbenzaldehyde for inhibition of the diphenolase activity of mushroom tyrosinase has been investigated.

Synthesis

The general procedure for the synthesis of 4-ethylbenzaldehyde from 1-ethyl-4-vinylbenzene was as follows: in a 50 mL two-necked round-bottomed flask, the substrate (1 mmol) was stirred and mixed with CoCN catalyst (0.02 g) in MeCN (5.0 mL). Subsequently, 30 wt% H2O2 (0.34 g) was slowly added to the reaction mixture and the reaction temperature was raised to 65 °C with continuous stirring for 6 hours. Upon completion of the reaction, the catalyst was separated by centrifugation and the product was extracted with EtOAc and saturated aqueous NaCl. The organic phase was dried with Na2SO4 and purified by column chromatography to give 4-ethylbenzaldehyde (Table 2, entry 16): colorless liquid; yield: 91 mg (91%).

References

[1] Synlett, 2018, vol. 29, # 16, p. 2181 - 2184

4-Ethylbenzaldehyde(4748-78-1)Related Product Information

• 3-(Trifluoromethyl)benzaldehyde
• 2-Nitrobenzaldehyde
• Benzaldehyde
• 4-Hydroxybenzaldehyde
• 3-(METHOXYMETHOXY)BENZALDEHYDE
• p-Tolualdehyde
• Salicylaldehyde
• 4-Dimethylaminobenzaldehyde
• p-Anisaldehyde
• 3-Methoxybenzaldehyde
• 4-CYANOPHENYL 4-N-BUTYLBENZOATE
• 4-N-HEPTYLBENZOYL CHLORIDE
• 2-Ethyl anthraquinone
• 4-CYANOPHENYL 4-HEPTYLBENZOATE
• 4'-CYCLOHEXYLACETOPHENONE
• 4-BROMOBENZHYDROL
• 4-N-HEXYLBENZOYL CHLORIDE
• 4-Ethylbenzoic acid