5,5'-DIMETHYL-2,2'-DIPYRIDYL Chemical Properties

Melting point:

114-117 °C(lit.)

Boiling point:

140℃/3mm

Density 

1.060±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMF: 15mg/mL,DMSO: 10mg/mL,Ethanol: 15mg/mL,Ethanol:PBS (pH 7.2) (1:4): 0.2mg/mL

form 

powder to crystal

pka

4.78±0.32(Predicted)

color 

White to Yellow to Orange

InChI

InChI=1S/C12H12N2/c1-9-3-5-11(13-7-9)12-6-4-10(2)8-14-12/h3-8H,1-2H3

InChIKey

PTRATZCAGVBFIQ-UHFFFAOYSA-N

SMILES

C1(C2=NC=C(C)C=C2)=NC=C(C)C=C1

CAS DataBase Reference

1762-34-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36

WGK Germany 

3

RTECS 

DW1766000

HS Code 

29333990

Toxicity

mouse,LD50,intraperitoneal,225mg/kg (225mg/kg),Toxicon. Vol. 23, Pg. 815, 1985.

MSDS

• Language:English Provider:SigmaAldrich

5,5'-DIMETHYL-2,2'-DIPYRIDYL Usage And Synthesis

Uses

5,5'-Dimethyl-2,2'-bipyridine is widely used as an intermediate in organic synthesis and pharmaceuticals. It is also used as a raw material in the synthesis of dyestuffs and agrochemicals. It is used as a precursor for the preparation of 5-methyl-5'vinyl-2,2'-bipyridine.

Definition

ChEBI: Abametapir is a member of bipyridines.

Mechanism of action

5 5'-Dimethyl-2,2-bipyridine works by inhibiting metalloproteinase enzymes that are essential for lice egg growth and development.

Synthesis

2-Amino-5-methylpyridine ((Abametapir))(100) was converted to 2-bromo-5-methylpyridine (101) via the Sandmeyer reaction using bromine and sodium nitrite in 75% yield. Next, 101 was converted to abametapir (XIV) via a palladium-catalyzed homocoupling reaction in 79% yield. Abametapir was finally isolated by crystallization from a water/isopropanol mixture.

5,5'-DIMETHYL-2,2'-DIPYRIDYL(1762-34-1)Related Product Information

• 4,4'-DIMETHYL-2,2'-DIPYRIDYL,4,4'-DIMETHYL-2,2'-DIPYRIDYL, SUBLIMED &,4,4'-Dimethyl-2,2'-dipyridyl ,98%
• 6,6-DIMETHYL-2,2-DIPYRIDYL
• Paraquat dichloride
• 2,2'-Bipyridine-5,5'-dicarboxylic acid
• Paraquat methosulfate
• Paraquat
• Streptonigrin
• 5,5'-DIMETHYL-2,2'-DIPYRIDYL
• 2,2'-Bipyridine
• lavendamycin
• 10'-desmethoxystreptonigrin
• 2,2'-Bipyridyl-5,5'-dialdehyde
• 4,4'-Dimethyl-2,2'-Dipyridyl,>99%
• 5,5'-DIMETHYL-2,2'-DIPYRIDYL-D12
• RARECHEM AN KD 0928
• 5,5'-DIMETHYL-1-(2-OXO-2-PHENYL-ETHYL)-[2,2']BIPYRIDINYL-1-IUM BROMIDE
• RARECHEM AN KA 0928
• RARECHEM AN KC 0921