2-Bromo-5-methylpyridine Chemical Properties

Melting point:

41-43 °C (lit.)

Boiling point:

95-96 °C/12.5 mmHg (lit.)

Density 

1.4964 (rough estimate)

refractive index 

1.5680 (estimate)

Flash point:

218 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Dimethyl Sulfoxide, Methanol,

form 

Low Melting Crystalline Solid or Crystals

pka

1.08±0.10(Predicted)

color 

White to light yellow or pale brown

BRN 

107323

InChI

InChI=1S/C6H6BrN/c1-5-2-3-6(7)8-4-5/h2-4H,1H3

InChIKey

YWNJQQNBJQUKME-UHFFFAOYSA-N

SMILES

C1(Br)=NC=C(C)C=C1

CAS DataBase Reference

3510-66-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

26-37/39-36/37/39-36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29333999

MSDS

• Language:English Provider:2-Bromo-5-methylpyridine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Bromo-5-methylpyridine Usage And Synthesis

Structure

The crystal structure of 2-bromo-5-methyl-pyridine was reported. The planar molecule lies on a crystallographic plane of symmetry, with a half molecule in the asymmetric unit. The only intermolecular interactions observed are weak tip-to-tail C3—H3···N1 interactions that form infinite chains along[100]. Similar C—H···N interactions have been observed in other5-substituted 2-bromopyridines, though not in the closely related 2,6-dibromo-3,5-dimethylpyridine.There are no other significant intermolecular interactions present[1].

Chemical Properties

2-Bromo-5-methylpyridine is Light Brown Solid

Uses

2-Bromo-5-methylpyridine is used for preparation of [[(triazolylmethyl)pyridyl]phenyl]tetrazoles and related compounds as cardiovascular agents.

Uses

2-Bromo-5-methylpyridine has been used as starting reagent for the synthesis of:

• 5,5′-dimethyl-2,2′-bipyridine
• 5-methyl-2,2′:6′,2″-terpyridine
• 5-bromo-5″-methyl-2,2′:6′,2″-terpyridine

References

[1] Mrittika Roy, David R. Manke, J. Golen. “2-Bromo-5-methyl-pyridine.” IUCrData 26 10 (2016).

2-Bromo-5-methylpyridine(3510-66-5)Related Product Information

• 6-Bromonicotinic acid
• 2-Chloro-5-chloromethylpyridine
• 4-Methylpyridine
• 1-Hexadecylpyridinium bromide
• 2,6-Lutidine
• 2,4,6-Collidine
• Azamethiphos
• 2-Bromo-5-nitropyridine
• 2-Bromo-5-(trifluoromethyl)pyridine
• 2-BROMO-6-METHYLPYRIDINE
• 2-BROMO-5-METHOXYPYRIDINE
• 2-Bromo-6-(trifluoromethyl)pyridine
• 2-BROMO-5-IODOBENZYL ALCOHOL
• 5-Amino-2-bromopyridine
• 2-BROMO-5-METHOXYANILINE
• 2-Bromo-5-chloropyridine
• 2-Bromo-5-fluoropyridine
• 2-BROMOMETHYL-PYRIDINE