E3 ligase Ligand-Linker Conjugates 36 Chemical Properties

Boiling point:

981.3±65.0 °C(Predicted)

Density 

1.239±0.06 g/cm3(Predicted)

pka

3.39±0.10(Predicted)

E3 ligase Ligand-Linker Conjugates 36 Usage And Synthesis

Uses

cIAP1 Ligand-Linker Conjugates 14 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 14 can be used to design SNIPERs[1].

IC 50

cIAP1

References

[1] Itoh Y, et al. Design, synthesis and biological evaluation of nuclear receptor-degradation inducers. Bioorg Med Chem. 2011 Nov 15;19(22):6768-78. DOI:10.1016/j.bmc.2011.09.041

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