Basic information Safety Supplier Related

E3 ligase Ligand 11

Basic information Safety Supplier Related

E3 ligase Ligand 11 Basic information

Product Name:
E3 ligase Ligand 11
Synonyms:
  • cIAP1 ligand 2
  • E3 ligase Ligand 11
  • Benzyl ((S)-1-(((S)-1-Cyclohexyl-2-((S)-2-(4-(3-hydroxybenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate
  • benzyl N-[(1S)-1-{[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(3-hydroxybenzoyl)-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxoethyl]carbamoyl}ethyl]-N-methylcarbamate
  • Carbamic acid, N-[(1S)-2-[[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(3-hydroxybenzoyl)-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]amino]-1-methyl-2-oxoethyl]-N-methyl-, phenylmethyl ester
CAS:
2357114-70-4
MF:
C34H40N4O6S
MW:
632.77
Mol File:
2357114-70-4.mol
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E3 ligase Ligand 11 Chemical Properties

Boiling point:
863.5±65.0 °C(Predicted)
Density 
1.286±0.06 g/cm3(Predicted)
pka
8.78±0.10(Predicted)
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E3 ligase Ligand 11 Usage And Synthesis

Uses

cIAP1 ligand 2 is the LCL161 derivative based IAP ligand. cIAP1 ligand 2 can be connected to the ABL ligand for protein by a linker to form SNIPER.

IC 50

cIAP1

References

[1] Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575. DOI:10.1021/acs.jmedchem.7b00168

E3 ligase Ligand 11Supplier

Daicel Chiral Technologies (China)CO.,LTD
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021-50460086-9 15921403865
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ShangHai Caerulum Pharma Discovery Co., Ltd.
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18149758185
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sales-cpd@caerulumpharma.com
Jilin Province Woda Biotechnology Co., Ltd.
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13504435624
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1927928688@qq.com
TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
ShenZhen Trendseen Biological Technology Co.,Ltd.
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13417589054;
Email
trendseenbio@gmail.com