E3 ligase Ligand-Linker Conjugates 33 Chemical Properties

Boiling point:

842.4±65.0 °C(Predicted)

Density 

1.214±0.06 g/cm3(Predicted)

pka

11.15±0.46(Predicted)

E3 ligase Ligand-Linker Conjugates 33 Usage And Synthesis

Uses

cIAP1 Ligand-Linker Conjugates 11 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 11 can be used to design SNIPERs[1].

IC 50

cIAP1

References

[1] Itoh Y, et al. Protein knockdown using methyl bestatin-ligand hybrid molecules: design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins. J Am Chem Soc. 2010 Apr 28;132(16):5820-6. DOI:10.1021/ja100691p

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• E3 ligase Ligand-Linker Conjugates 34
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