Pamrevlumab
Pamrevlumab Basic information
- Product Name:
- Pamrevlumab
- Synonyms:
-
- Pamrevlumab
- Research Grade Pamrevlumab(DHD82301)
- Research Grade Pamrevlumab
- Pamrevlumab (anti-CTGF)
- FG-3019
- CAS:
- 946415-13-0
- MW:
- 0
- Mol File:
- Mol File
Pamrevlumab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
Pamrevlumab Usage And Synthesis
Uses
FG-3019 (Pamrevlumab) is a recombinant human antibody that binds to connective tissue growth factor (CTGF). FG-3019 can be used for the research of idiopathic pulmonary fibrosis (IPF)[1][2].
in vivo
FG-3019 (30 mg/kg; i.p. every 3 d for 9 d) in combination with Gemcitabine acutely decreases mouse pancreatic ductal adenocarcinoma (PDA) growth and induces neoplastic cell apoptosis in LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) mice[2].
References
[1] Sgalla G, et, al. Pamrevlumab for the treatment of idiopathic pulmonary fibrosis. Expert Opin Investig Drugs. 2020 Aug;29(8):771-777. DOI:10.1080/13543784.2020.1773790
[2] Neesse A, et, al. CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12325-30. DOI:10.1073/pnas.1300415110
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